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Evaluation of the biological activity of nuclear EGFR. a. HUVEC proliferation were significantly reduced in non-EGFR nuclear localization group by MTT analysis. b. The nuclear-localized EGFR is involved in the cell cycle. c. the expression of cyclinD1, CDK4, Ki67 and Rb were down-regulated.Data are presented as mean ± SD (n = 5). Asterisks indicate statistically significant differences.
