Table 1.
Group Characteristics
| CI (n = 30) | AD (n = 30) | p Value | |
|---|---|---|---|
| Age, mean (SD) | 90.2 (5.1) | 90.11 (5.7) | NA |
| Sex, male, n (%) | 5 (17) | 5 (17) | NA |
| Education, years, median (IQR) | 18 (21–16) | 18 (21–18) | .73 |
| BMI, median (IQR) | 24.0 (25.2–22.6) | 24.8 (29–23.4) | .29 |
| Walking speed, m/s, mean (SD) | 0.63 (0.24) | 0.56 (0.19) | .34 |
| Grip strength, kg, mean (SD) | 33.5 (15.1) | 30.1 (10.4) | .50 |
| Frailty score, median (IQR) | 0.45 (1.57–0.01) | 0.55 (1.02–0.12) | .68 |
| GCF score, mean (SD) | 0.13 (0.48) | −2.04 (1.12) | <.001* |
| GCF score decline per year, mean (SD) | 0.03 (0.09) | 0.18 (0.11) | <.001* |
| MMSE, median (IQR) | 28 (28–30) | 14 (3–21) | <.001* |
| Coronary artery disease, n (%) | 7 (23.3) | 7 (23.3) | 1 |
| Stroke, n (%) | 6 (20) | 6 (20) | 1 |
| Cancer, n (%) | 12 (40) | 9 (30) | .42 |
| Hypertension, n (%) | 16 (53.3) | 25 (83.3) | .01* |
| Thyroid disease, n (%) | 5 (16.7) | 11 (36.7) | .08 |
| Claudication, n (%) | 5 (16.7) | 11 (36.7) | .08 |
| Diabetes, n (%) | 3 (10) | 7 (23.3) | .17 |
| Systolic BP mean (SD) | 123.85 (19.22) | 133.69 (15.78) | .06 |
| Diastolic BP mean (SD) | 67.45 (9.74) | 72.04 (11.59) | .19 |
| PMI, hours, median (IQR) | 5.63 (15.33–4.27) | 6.93 (10.58–4.25) | .98 |
| Overall amyloid-β score, median (IQR) | 3.16 (1.12–5.7) | 6.19 (1.8–8.53) | .04* |
| Hippocampal amyloid-β score, median (IQR) | 1.15 (0–2.04) | 2.39 (0.56–3.86) | .01* |
| Superior frontal amyloid-β score, median (IQR) | 3.14 (0.75–10.03) | 5.49 (2.09–9.38) | .88 |
| Midfrontal gyrus amyloid-β score, median (IQR) | 4.96 (0.61–11.57) | 7.69 (3.20–12.07) | .04* |
| Overall tangle score, median (IQR) | 1.47 (0.57–4.70) | 6.44 (4.85–16.97) | <.001* |
| Hippocampal tangle score, median (IQR) | 4.18 (2.20–16.46) | 30.64 (14.76–38.67) | <.001* |
| Superior frontal tangle score, median (IQR) | 0.01 (0–0.16) | 1.02 (0.01–6.92) | .006* |
| Midfrontal gyrus tangle score, median (IQR) | 0.001 (0–0.1) | 0.27 (0.01–6.35) | .001* |
Notes: AD = Alzheimer’s dementia; BMI = body mass index; BP = blood pressure; CI = cognitively intact; GCF = global cognitive function; IQR = interquartile range; MMSE = Mini-Mental State Examination; PMI = postmortem interval; SD = standard deviation; NA = not applicable.
*p ≤ .05.