Table 1.
Visit 2 Participant Characteristics by Most Severe (PFS Physical Scores ≥ 25) Versus Less Severe (PFS Physical Scores < 25) Perceived Physical Fatigability (N = 2 258)
| All (N = 2 258) | Most Severe Fatigability (n = 365) | Less Severe Fatigability (n = 1 893) | p-Value | |
|---|---|---|---|---|
| Number of deaths | 230 (10.2) | 147 (40.3) | 83 (4.4) | <.0001 |
| Age, y | 73.5 ± 10.4 | 85.4 ± 12.6 | 71.2 ± 8.2 | <.0001 |
| Sex, women | 1 235 (54.7) | 236 (64.7) | 999 (52.7) | <.0001 |
| Physical activity, MET-h/d* | 36.4 ±7.0 | 30.4 ± 5.6 | 37.5 ± 6.7 | <.0001 |
| Heart disease† | 143 (6.3) | 50 (13.7) | 93 (4.9) | <.0001 |
| Hypertension‡ | 1 354 (60.0) | 232 (63.6) | 1 122 (59.3) | .13 |
| Stroke† | 115 (5.1) | 52 (14.3) | 63 (3.3) | <.0001 |
| Kidney disease† | 75 (3.3) | 28 (7.7) | 47 (2.5) | <.0001 |
| Diabetes§ | 252 (11.2) | 67 (18.4) | 185 (9.8) | <.0001 |
| Peripheral arterial disease† | 53 (2.4) | 32 (8.7) | 21 (1.1) | <.0001 |
| Liver disease† | 65 (2.9) | 7 (1.9) | 58 (3.1) | .23 |
| Lung disease† | 306 (13.6) | 68 (18.6) | 238 (12.6) | .002 |
| Cancer (excluding skin)† | 563 (25.0) | 132 (36.2) | 431 (22.8) | <.0001 |
| Depressive symptomatology, 0–30‖ | 3.2 ± 3.5 | 5.5 ± 4.6 | 2.8 ± 3.1 | <.0001 |
| Smoking status | ||||
| Former smoker | 877 (38.8) | 142 (38.8) | 735 (38.8) | .99 |
| Current smoker | 87 (3.9) | 7 (1.9) | 80 (4.2) | .04 |
| Nonsmoker | 1 294 (57.3) | 216 (59.8) | 1 078 (57.0) | .43 |
| Follow-up time, y | 2.7 ± 1.0 | 2.6 ± 1.3 | 2.8 ± 1.0 | .007 |
Notes: PFS = Pittsburgh Fatigability Scale. All reported in mean ± SD or n (%).
*Framingham Physical Activity Index score.
†Self-reported doctor diagnosis (prevalence/history).
‡Hypertension defined as systolic ≥ 130 mm Hg and/or diastolic ≥ 80 mm Hg or taking blood pressure medication.
§Hemoglobin A1c ≥ 6.5%, fasting glucose ≥ 126 mg/dL, or self-reported doctor diagnosis defined diabetes.
‖Center for Epidemiological Studies—Depression Scale.