Table 2.

Cox Proportional Hazards Models Examining the Association of Most Severe (PFS Physical Scores ≥ 25) Versus Less Severe (PFS Physical Scores < 25) Perceived Physical Fatigability on 2.7-Year Survival^* (N = 2 258)

Models		Hazard Ratio (95% Confidence Interval)	p-Value
	Unadjusted	9.34 (7.13–12.24)	<.0001
1	Accounting for family relatedness and adjusted for field center	10.20 (7.64–13.66)	<.0001
2	Model 1 plus age and sex	2.93 (2.10–4.10)	<.0001
3	Model 2 plus physical activity score†	2.60 (1.85–3.66)	<.0001
4	Model 3 plus health conditions‡	2.29 (1.63–3.21)	<.0001
5	Model 4 plus smoking history§	2.33 (1.65–3.28)	<.0001

Note: PFS = Pittsburgh Fatigability Scale.

*Mean 2.7 ± 1.0 years follow-up.

^†Framingham Physical Activity Index score dichotomized at the median=35.4 MET-h/d.

^‡Heart disease, stroke, kidney disease, peripheral artery disease, liver disease, lung disease, and cancer (not including skin) all self-report prevalence/history; hypertension defined as systolic ≥ 130 mm Hg and/or diastolic ≥80 mm Hg or taking blood pressure medication; hemoglobin A1c ≥ 6.5%, fasting glucose ≥ 126 mg/dL, or self-reported doctor diagnosis defined diabetes.

^§Former, current smoker, or nonsmoker.