Table 1.
Demographics, comorbidities, and outcomes among patients with a history of cancer diagnosed and hospitalized with COVID-19.
| Patients with history of cancer diagnosed with COVID-19 | Patients with history of cancer hospitalized with COVID-19 | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SIDIAP | CU-AMC-HDC | CUIMC | Health Verity | IQVIA-Open Claims | Optum-EHR | STARR-OMOP | VA-OMOP | SIDIAP | CU-AMC-HDC | CUIMC | Health Verity | IQVIA-Open Claims | Optum-EHR | STARR-OMOP | VA-OMOP | |
| Characteristics, in % | n = 8,854 | n = 806 | n = 1,433 | n = 4,857 | n = 315,523 | n = 22,996 | n = 821 | n = 10,760 | n = 2,610 | n = 265 | n = 561 | n = 797 | n = 105,931 | n = 5,806 | n = 244 | n = 3,383 |
| Sex | ||||||||||||||||
| Female | 53.9 | 53.0 | 54.7 | 53.7 | 55.1 | 58.6 | 47.0 | 7.1 | 39.7 | 46.8 | 46.3 | 50.1 | 48.7 | 50.3 | 41.8 | 3.6 |
| Male | 46.1 | 47.0 | 45.3 | 46.3 | 44.9 | 41.4 | 53.0 | 92.9 | 60.3 | 53.2 | 53.7 | 49.9 | 51.3 | 49.7 | 58.2 | 96.4 |
| Race, African American | — | 5.6 | 9.7 | — | — | 11.5 | — | 29.0 | — | 9.1 | 10.0 | — | — | 14.2 | — | 35.1 |
| Antineoplastic and immunomodulating agents | ||||||||||||||||
| The month prior | 10.9 | 22.5 | 12.3 | 5.4 | 9.8 | 6.3 | 18.8 | 12.0 | 10.8 | 28.3 | 14.6 | 5.9 | 10.7 | 10.9 | 18.9 | 14.2 |
| The year prior | 13.6 | 35.1 | 24.6 | 20.3 | 18.0 | 16.3 | 31.9 | 21.5 | 13.7 | 37.7 | 26.0 | 18.6 | 19.9 | 20.7 | 29.9 | 24.1 |
| Comorbidities | ||||||||||||||||
| Asthma | 4.7 | 15.4 | 20.5 | 9.9 | 17.2 | 20.3 | 14.3 | 10.8 | 3.9 | 12.1 | 22.8 | 10.0 | 16.3 | 15.8 | 16.4 | 9.9 |
| COPD | 33.7 | 23.7 | 19.8 | 17.3 | 26.8 | 18.4 | 11.9 | 43.3 | 41.5 | 29.4 | 28.2 | 31.4 | 34.8 | 28.6 | 11.1 | 53.2 |
| Type 2 diabetes | 17.8 | 26.9 | 38.0 | 31.7 | 47.5 | 29.9 | 22.0 | 50.3 | 22.5 | 36.2 | 55.1 | 43.0 | 56.9 | 40.5 | 23.8 | 58.7 |
| Hyperlipidemia | 22.8 | 38.7 | 30.8 | 40.1 | 38.4 | 44.7 | 38.7 | 58.8 | 24.6 | 42.3 | 38.0 | 48.4 | 41.5 | 49.1 | 44.3 | 61.2 |
| Obesity | 41.8 | 49.3 | 52.8 | 21.8 | 35.5 | 60.4 | 40.0 | 52.7 | 47.8 | 52.1 | 57.0 | 25.7 | 38.8 | 60.4 | 39.8 | 53.4 |
| Heart disease | 34.3 | 50.0 | 62.8 | 39.9 | 68.1 | 51.1 | 40.8 | 71.4 | 41.6 | 59.2 | 76.5 | 60.9 | 78.6 | 63.9 | 45.5 | 79.1 |
| Hypertension | 33.2 | 60.2 | 70.0 | 58.1 | 80.8 | 61.3 | 52.4 | 86.7 | 37.3 | 69.4 | 83.1 | 74.4 | 89.4 | 73.3 | 58.2 | 92.8 |
| Anxiety | 24.2 | 19.1 | 12.2 | 13.5 | 13.5 | 18.6 | 16.6 | 31.1 | 19.3 | 18.1 | 10.7 | 19.4 | 14.2 | 18.2 | 18.9 | 30.1 |
| Dementia | 10.7 | 5.8 | 11.0 | 7.1 | 18.3 | 6.3 | 1.7 | 14.3 | 7.2 | 7.5 | 21.2 | 15.8 | 21.5 | 10.8 | — | 23.7 |
| Depression | 7.2 | 9.2 | 14.8 | 2.7 | 12.3 | 10.9 | 10.4 | 21.1 | 5.7 | 9.1 | 20.0 | 4.9 | 12.7 | 9.6 | 12.7 | 19.1 |
| Anemia | 19.6 | 22.1 | 19.3 | 24.8 | 24.8 | 18.0 | 24.7 | 25.8 | 20.0 | 35.1 | 25.0 | 40.9 | 33.3 | 29.1 | 32.0 | 36.7 |
| Autoimmune condition | 10.4 | 19.9 | 30.8 | 13.0 | 32.0 | 18.3 | 14.6 | 30.3 | 11.2 | 20.0 | 38.1 | 17.8 | 36.2 | 20.8 | 11.9 | 35.4 |
| Chronic kidney disease | 19.4 | 23.8 | 27.4 | 18.4 | 31.7 | 27.9 | 18.0 | 34.1 | 23.6 | 34.0 | 40.8 | 36.0 | 44.1 | 39.2 | 20.1 | 44.3 |
| Chronic liver disease | 1.9 | 3.2 | 3.6 | 2.2 | 2.0 | 2.4 | 7.3 | 6.1 | 1.8 | 4.9 | 5.0 | 4.0 | 3.0 | 3.5 | 4.9 | 8.8 |
| Outcomes | ||||||||||||||||
| Death | 14.4 | — | 10.4 | — | — | 1.7 | — | 7.6 | 21.4 | — | 26.2 | — | — | 5.5 | — | 18.1 |
| Hospitalization | 24.9 | — | 34.8 | 13.5 | 32.1 | 24.1 | 27.0 | 27.1 | NA | NA | NA | NA | NA | NA | NA | NA |
| Intensive services requirement | NA | NA | NA | NA | NA | NA | NA | NA | — | — | — | — | 8.7 | 13.0 | 5.7 | 16.0 |
| ARDS during hospitalization | NA | NA | NA | NA | NA | NA | NA | NA | — | — | 15.9 | 26.5 | 33.3 | 41.8 | 8.2 | 41.2 |
| Cardiovascular disease events | NA | NA | NA | NA | NA | NA | NA | NA | — | — | 6.8 | 10.8 | 11.2 | 16.7 | 8.2 | 20.8 |
| Deep vein thrombosis events | NA | NA | NA | NA | NA | NA | NA | NA | — | — | 2.1 | 3.0 | 2.4 | 4.0 | — | 4.8 |
| Pulmonary embolism events | NA | NA | NA | NA | NA | NA | NA | NA | — | — | 2.7 | 2.1 | 2.1 | 3.5 | — | 4.0 |
| Acute kidney injury during hospitalization | NA | NA | NA | NA | NA | NA | NA | NA | — | — | 16.0 | 11.4 | 9.6 | 16.6 | 11.9 | 14.4 |
| Sepsis during hospitalization | NA | NA | NA | NA | NA | NA | NA | NA | — | — | 6.1 | 17.7 | 18.4 | 25.0 | 9.8 | 20.5 |
Notes: — indicates data not available or below the minimum cell count required (5 individuals); NA indicates not applicable.