Table 1.
Patient characteristics, comorbidities, sleep study parameters, and PAP adherence.
| OSA (n = 36) | OHS (n = 15) | P | |
|---|---|---|---|
| Demographics | |||
| Age | 48 ± 2.3 | 53 ± 3.2 | ns |
| Male, n (%) | 15 (42) | 4 (27) | ns |
| BMI (kg/m2) | 50 (13) | 58 (21) | ns |
| Ethnicity, n (%) | |||
| Caucasian | 23 (64) | 8 (53) | ns |
| Pacific Islander | 7 (19) | 4 (27) | ns |
| Aboriginal | 3 (8) | 1 (6) | ns |
| Epworth sleepiness score | 13 ± 6.0 | 14 ± 6.9 | ns |
| Never smoker, n (%) | 20 (55) | 4 (27) | ns |
| Pack-years | 0 (13) | 10 (20) | ns |
| Comorbidities, n (%) | |||
| Diabetes | 15 (42) | 9 (60) | ns |
| Hypertension | 21 (58) | 8 (53) | ns |
| Hypercholesterolemia | 5 (14) | 4 (27) | ns |
| Depression | 4 (11) | 4 (27) | ns |
| Stroke | 1 (0.03) | 0 (0) | ns |
| Coronary artery disease | 5 (0.14) | 1 (0.06) | ns |
| Medications, n (%) | |||
| ACE-inhibitor/ARB | 18 (50) | 6 (40) | ns |
| Beta-blocker | 6 (17) | 4 (27) | ns |
| Diuretic | 7 (19) | 1 (6) | ns |
| Aspirin or anticoagulant | 6 (17) | 6 (40) | ns |
| Cholesterol-lowering agent | 12 (33) | 6 (40) | ns |
| Oral hypoglycemic agent | 16 (44) | 6 (40) | ns |
| Diagnostic sleep study parameters | |||
| AHI (events/h) | 71 ± 31.2 | 78 ± 47.4 | ns |
| Minimum SpO2 (%) | 63 ± 18.8 | 48 ± 16.1 | < .01 |
| TST with SpO2 < 90% (min) | 140 ± 149.2 | 308 ± 139.6 | < .01 |
| TST with SpO2 < 80% (min) | 55 ± 19.9 | 112 ± 107.7 | ns |
| PAP compliance (minutes) | 317.9 ± 92.9 | 375.1 ± 102.1 | ns |
| % Days with > 4 hours use | 73 ± 26 | 80 ± 15.6 | ns |
| Daytime PaCO2 (mm Hg) | |||
| Visit 1 | 40 (7) | 49 (6) | < .01 |
| Visit 2 | 42 (4) | 43 (6) | ns |
| Daytime SpO2 (mm Hg) | |||
| Visit 1 | 96 (2) | 93 (5) | < .01 |
| Visit 2 | 96 (2) | 95 (1) | < .01 |
Data are presented as mean ± standard deviation or median (interquartile range) unless otherwise stated. ACE = angiotensin-converting enzyme, AHI = apnea-hypopnea index, ARB = angiotensin receptor blocker, BMI = body mass index, ns = not significant, OHS = obesity hypoventilation syndrome, OSA = obstructive sleep apnea, PaCO2 = partial pressure of carbon dioxide, PAP = positive airway pressure, SpO2 = oxygen saturation by pulse oximetry, TST = total sleep time.