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Correlation between cortical DNA radioactivity (A) or frequency of labeled cells in cortex (B) and apoptosis (detected by TUNEL) in controls and in animals treated for 10 days with gentamicin at 10 or 20 mg/kg. Curvilinear, polynomial functions were fitted by GraphPad software (for panel A, r = 0.90, n = 36, and P < 0.01; for panel B, r = 0.88, n = 18, and P < 0.01) after a first analysis disclosed a statistically significant nonlinear relationship.
