TABLE 2.
Cortical (drug content and phospholipids), urinary phospholipiduria, and serum (creatinine and BUN) parameters in control rats and in rats treated with gentamicin and netilmicin
| Sample type and parameter | Value (mean ± SD) at daily dosage (mg/kg)a
|
||||
|---|---|---|---|---|---|
| 0 (controls) | Gentamicin
|
Netilmicin
|
|||
| 10 | 20 | 10 | 20 | ||
| Cortex | |||||
| Drug contentb | NA | 9.3 ± 2.7 | ND | 9.3 ± 1.9 | 12.2 ± 1.9 |
| Phospholipidsc | 100.0 ± 5.0 | 118.9 ± 6.1f | 111.4 ± 15.1 | 132.7 ± 5.1fh | 139.2 ± 8fh |
| Urine | |||||
| Phospholipiduriad | 100.0 ± 18.7 | 373.2 ± 30.8f | 488.8 ± 88.8fg | 564.3 ± 48.1fh | 714.7 ± 99.5fgh |
| Serume | |||||
| Creatinine | 0.6 ± 0.1 | 0.6 ± 0.1 | 1.2 ± 0.6 | 0.7 ± 0.1 | 0.7 ± 0.1 |
| BUN | 37.2 ± 10.5 | 32.7 ± 6.3 | 75.7 ± 52.3 | 27.3 ± 5.0 | 33.3 ± 7.8 |
a
Daily dosage administered for 10 days in two separate administrations at 9 a.m. and 5 p.m. NA, not applicable; ND, not determined.
b
Micrograms per milligram of protein.
c
Percentage of control value (controls, 323 ± 16 nmol/mg of protein).
d
Percentage of control value (controls, 122.12 ± 22.87 nmol/24 h).
e
Milligrams per deciliter.
f
Significantly different from controls.
g
Significantly different from the group treated at the lower dose.
h
Significantly different from the other aminoglycoside at the same dosage.