Sensitivity analysis. A, Predicted life years-gained (LYG), B, Colorectal cancer incidence and mortality reduction for triennial multitarget stool DNA (mt-sDNA) and annual fecal immunochemical test (FIT) in 3 different adherence scenarios. Results are per 1,000 individuals free of diagnosed colorectal cancer at age 40 and screened between 50 and 75 years. S1, 100% screening adherence and 100% colonoscopy follow-up adherence; S2, sensitivity analysis rates for reported screening adherence and 100% colonoscopy follow-up adherence; S3, sensitivity analysis rates for reported screening adherence and reported colonoscopy follow-up adherence.