Table 2.
Families of fish allergens.
| Protein family | Molecular mass (kDa) | Frequency of IgE binding (%) | Number of registered allergens | Example |
|---|---|---|---|---|
| β-Parvalbumin | 12 | 80–100 | 16 | Gad m 1 (Gadus morhua, Atlantic cod) |
| β-Enolase | 47 | 20–60 | 5 | Sal s 2 (Salmo salar, Atlantic salmon) |
| Aldolase A | 40 | 10–40 | 4 | Thu a 3 (Thunnus albacares; yellowfin tuna) |
| Tropomyosin | 33 | 6–34 | 3 | Ore m 4 (Oreochromis mossambicus; Mozambique tilapia) |
| Collagen type I α1-chain | 130–140 | 22 | 2 | Lat c 6 (Lates calcarifer; Barramundi) |
| Creatine kinase | 43 | 10–14 | 2 | Sal s 7 (Salmo salar, Atlantic salmon) |
| Triosephosphate isomerase | 27 | 20–30 | 2 | Pan h 8 (Pangasianodon hypophthalmus; striped catfish) |
| Pyruvate kinase | 59 | 8 | 1 | Pan h 9 (Pangasianodon hypophthalmus; striped catfish) |
| Lactate dehydrogenase | 36 | 15 | 1 | Pan h 10 (Pangasianodon hypophthalmus; striped catfish) |
| Glucose 6-phosphate isomerase | 62 | 6 | 1 | Pan h 11 (Pangasianodon hypophthalmus; striped catfish) |
| Glyceraldehyde-3-phosphate dehydrogenase | 37 | 8 | 1 | Pan h 13 (Pangasianodon hypophthalmus; striped catfish) |
| Vitellogenin | 19 | 100a | 1 | Onc k 5 (Oncorhynchus keta; chum salmon) |
a
Among patients allergic to chum salmon roe.
Data were compiled from the WHO/IUIS Allergen Nomenclature Database (www.allergen.org, accessed on June 25th 2021).