Table 2.
Patient demographics, reaction to first vaccine dose, treatment of reaction, latency period between first dose, and allergist evaluation, result of PEG SPT and response to desensitization.
| Patient | Gender Age | Ethnicity | Comorbidities | Allergy labels | Reported symptoms first vaccine dose | PEG SPT result | Vaccine type | Desensitization |
|---|---|---|---|---|---|---|---|---|
| 1 | F 49 | Aboriginal | Anemia Neuropathic pain | Amoxicillin Cefazolin Azithromycin Shellfish | 15 min: generalized erythema, urticarial, and dyspnea | Delayed positive (3 h) Cremophor EL | mRNA (Moderna) | First dose: itchiness Second dose: increased itchiness (no hives) Treatment: cetirizine 20 mg PO Fourth dose: cough and globus sensation |
| 2 | F 66 | East Asian | Steroid-dependent spondylarthritis Colitis | Pneumococcal conjugate vaccine Recombinant zoster vaccine Anileridine Infliximab | 30 min: generalized urticaria 24 h: angioedema eyes and lips | Delayed positive (5 h) Cemophor EL PEG 300 PEG 3000 PEG 3350 | mRNA (Moderna) | Premedication: Rupatadine 20 mg PO Prednisone 10 mg PO |
| 3 | F 64 | Caucasian | CSU Diverticulosis Hypothyroidism Oral lichen planus | Rabies vaccine | 15 min: dizziness, itchiness of her feet, hands, arms, and throat with visible urticaria | Negative Histamine –Negative | mRNA (Moderna) | Premedication: Bilastine 40 mg. Third dose: headache Treatment: Acetaminophen |
| 4 | F 35 | Caucasian | None | Penicillin Cephalosporin |
15 min: throat itchiness and difficulty swallowing, nausea, vomiting, and lightheaded | Negative | mRNA (Pfizer-BioNTech) | Third dose: itchy arms and right ear pressure. 120 min after third dose: dizziness and drop in systolic BP Treatment: cetirizine 20 mg and IV fluid bolus |
| 5 | F 57 | Caucasian | Bronchial Asthma Ehlers-Danlos syndrome Osteopenia | Septra | 20 min: facial numbness and swelling, cough and difficulty breathing, hoarseness, and chest pain | Negative | mRNA (Pfizer-BioNTech) | Third dose: tongue tingling. 1 week: maculopapular rash, desquamation of the skin. Treatment: desloratadine 10 mg PO, mometasone cream topical application. |
| 6 | F 33 | Hispanic | Asthma Depression Post-traumatic stress disorder | Codeine Shellfish Peanut | 10 min: throat itchiness and swelling, wheezing, vomiting, generalized numbness | Negative | mRNA (Pfizer-BioNTech) | Premedication: Cetirizine 40 mg PO Placebo: neck itchiness First dose: muscle spasms |
BP, blood pressure; CSU, chronic spontaneous urticaria; F, female; PO, by mouth.