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. 2022 Apr 1;189(4):171. doi: 10.1007/s00604-022-05272-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Bar diagrams of the % signal increase after the hybridization with 50 fM: a 74 nts CoV-2-R-DNA74 complementary sequence or GFP-NC-DNA72 non-complementary sequence; b CoV-2-R-RNA100 sequence or CoV-2-R-NC-RNA126 non-complementary sequence; c SNP (CoV-2-S-DNA72-SNP) and complementary (CoV-2-S-DNA72) sequence and d samples of SARS-CoV-2 infected patients P1 (19 Cts), P2 (22 Cts), P3 (25 Cts), P4 (32Cts) and non-infected patient used as control (Control). Data are presented as mean ± SD (n = 3) in terms of relative signal increase vs the control. Statistical analysis was performed using either ANOVA (Tukey’s test) or Student’s T test. Significant codes: ANOVA 0 “***” 0.001 “**” 0.01 “*” 0.05 “.” 0.1 “” 1 “.” and T test p value < 0.05 (sig)