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. 2020 Jul 10;225(7):1284–1295. doi: 10.1093/infdis/jiaa416

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© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 7. — Liver kinase B1 (LKB1) deficiency leads to a reduced number of alveolar macrophages (AMs) in the lung. A, Macrophage (CD45⁺, MerTK⁺, and CD64⁺) populations in lung suspensions of LysM-cre × Stk11^fl/fl and littermate control (Stk11^fl/fl) mice: “classic” AMs (cAMs) (SiglecF^high and CD11b^neg), “nonclassic” AMs (ncAMs) (SiglecF^low and CD11b^pos), and interstitial macrophages (IMs) (SiglecF^neg and CD11b^high). B–D, Numbers of cAMs, ncAMs, and IMs (B), percentage of dead cells (C), and percentage Ki-67–positive cells (D) in lung suspensions of LysM-cre × Stk11^fl/fl mice and littermate controls (Stk11^fl/fl). Data are shown as bar graphs representing mean with standard error of the mean for 5 mice per group. LysM-cre × Stk11^fl/fl mice were compared with littermate control (Stk11^fl/fl) mice using Student t tests. *P < .05; †P < .01; ‡P < .001.