Figure 3.

Image of agarose gel (1%) electrophoresis of long-range PCR products covering the whole SERPING1 gene. M: GeneRuler 1 kb plus DNA ladder (Thermo Scientific, Waltham, MA, USA). PCR products in lines involve the following exons: lines 1: exons 1–3 (from the binding site of the MLPA probe specific for exon 1), lines 2: exons 3–5, lines 3: exons 5–7, lines 4: exons 7–8, lines 5: exon 8 (plus an extra 1375 bp downstream from the 3'-end of exon 8). Samples marked with A (1A−5A) are derived from a C1-INH-HAE patient, samples with B (1B−5B) are from a healthy control.