Table 2.

Passive immunization with or topical application of monoclonal allergen-specific IgG antibody for treatment of IgE-mediated allergy.

Passive immunization	Topical application
Requires IgE blocking antibodies	May be performed with single non-IgE blocking antibodies
Requires full antibodies with long serum half-life	Can be done with antibody fragments or small scaffolds
Works only for certain less complex allergens and allergen sources	Can be used for complex allergens and allergen sources
One systemic administration sufficient for up to 3 months	Daily topical administration
Only for allergy treatment	Suitable also for treatment of RV infections with a blocking ICAM-1 antibody