TABLE 2.

RMSE of evaluated dosing regimens.

Scenario	Description	Clearance	Volume 1	Tm	Vmax	Km
Scenario 0	Hourly samples	0.28	0.26	7.55	1.73	17.88
Scenario 1	1 sample 1 day	2.43	1.23	16.61	1.80	17.88
Scenario 2	2 samples 1 day	2.25	1.20	13.53	1.79	17.89
Scenario 3	4 samples 2 days	1.34	0.92	13.29	1.79	17.89
Scenario 4	5 samples 2 days	1.04	0.92	11.93	1.79	17.89
Scenario 5	5 samples 3 days	1.36	0.80	13.29	1.79	17.89
Scenario 6	6 samples 3 days	0.59	0.82	12.72	1.79	17.89
Scenario 7	8 samples 3 days	0.58	0.81	11.32	1.79	17.89

Root mean square error (RMSE) after stochastic simulation and estimation for optimal sampling. A lower RMSE (range 0–∞) means less error in estimation of the parameter at hand. No interindividual variability is included on K21 and Tmax, therefore the RMSE, is 0 in all scenarios.