Table 1.

Eligible preschoolers for home peanut oral immunotherapy.

Eligible (need to fulfil all criteria)

Either failed baseline OFC with cumulative dose <300 mg protein, or objective reactions reported by caregiver with objective evidence of peanut sensitization

Grade 1 to 3 objective allergic reactions to peanut during OFC or reported by caregiver*

Objective evidence of peanut sensitization

• SPT ≥ 3mm, and/or

• peanut sIgE ≥ 0.35kU/L

Ineligible (if fulfil any one criteria)

Grade 4 severe allergic reaction to peanut during OFC or reported by caregiver*

Previous allergic reactions requiring epinephrine to any food

Significant patient or caregiver anxiety preventing initiation of OIT at home

Peanut naïve#

Threshold for reaction at baseline OFC less than 10 mg protein

Limited access to emergency care, e.g. patients who live > 30 min from emergency services

^*World Allergy Organization Subcutaneous Immunotherapy Systemic Reaction Grading System (13).

^#Suggest introduce peanut at home or arrange observed ingestion/oral food challenge.

OFC, oral food challenge; OIT, oral immunotherapy; sIgE, specific immunoglobulin E; SPT, skin prick test.