Table 2.
Baseline characteristics and Outcomes.
| Age at start of OIT (months) | Other food allergies | Co-morbidities | Pre-OIT peanut first reaction grade, age and symptoms | Pre-OIT peanut SPT (mm) | Pre-OIT peanut sIgE (kU/L) | Cumulative threshold by OFC | Progress on last follow up | Duration of build-up | Immediate reactions during build-up and grade | Dose achieved (mg protein) |
|---|---|---|---|---|---|---|---|---|---|---|
| 13* | None | Atopic dermatitis | Grade 2, 5 months—facial urticaria, vomiting | 6 mm | N/A | N/A | Completed build-up phase | 11 weeks | Grade 1 – Facial urticaria | 320 mg |
| 14** | Egg | None | Grade 1, 12 months—torso and face urticaria | 15 mm | 1.3 | 80 mg | Completed build-up phase | 11 weeks | Grade 1 – Facial urticaria | 320 mg |
| 37* | None | Atopic dermatitis | Grade 1, 6 months old—perioral non-urticarial rash | 7 mm | >100 | N/A | Completed build-up phase | 12 weeks | Grade 1 – occasional pruritis Grade 2 – Abdominal pain | 320 mg |
| 9* | Milk | Atopic dermatitis | Grade 1, 7 months—Generalized urticaria | 12 mm | N/A | N/A | Completed build-up phase | 20 weeks | Grade 1 – Facial urticaria | 320 mg |
| 9* | Egg | Atopic dermatitis | Grade 1, 4 months—Contact Urticaria on the face | 7 mm | 7.63 | N/A | Completed build-up phase | 20 weeks | Grade 1 – Abdominal Urticaria | 320 mg |
| 12* | None | Atopic dermatitis | Grade 1, 6 months—perioral urticaria | 8 mm | N/A | N/A | Completed build-up phase | 20 weeks | Grade 1 – Facial urticaria | 320 mg |
| 12* | FPIES to egg | Atopic dermatitis | Grade 2, 7 months—Generalized urticaria, angioedema and vomiting | 6 mm | N/A | N/A | Completed build-up phase | 28 weeks | Grade 1 – Oral pruritus | 320 mg |
| 13** | FPIP to dairy | Atopic dermatitis | Grade 1, 11 months—generalized urticaria | 4 mm | N/A | 150 mg | Completed build-up phase | 28 weeks | Grade 1 – Facial urticaria Grade 2 – diarrhea | 320 mg |
| 23* | None | Atopic dermatitis | Grade 2, 8 months—face, arms and torso urticarial swollen eyelids and ears | 4 mm | 11.8 | N/A | Building-up | In build-up at 24 weeks | Grade 2 – Vomited once; diarrhea during the first 10 doses. Grade 1 – Urticaria with subsequent updosing | 125 mg |
FPIES, Food Protein-Induced Enterocolitis Syndrome; FPIP, Food Protein Induced Proctocolitis; N/A, not available; OIT, oral immunotherapy; SPT, skin prick test.
*
History of objective allergic reactions reported by parents.
**
Baseline oral food challenges performed.
All mg amounts are mg protein.