Figure 2.

Epigenetic factors of HSC homeostasis and potential applications. Epigenetic factors including DNA methylation, histone modification, chromatin remodeling, non-coding RNAs, and RNA modification have been identified in recent decades. These factors are interactive and are essential for the regulation of HSC homeostasis. Understanding the regulatory mechanisms of these factors may unleash huge potential of HSCs in clinic such as blood disease diagnosis, developing chemical and gene therapies through expanding HSCs or slowing down their aging.