TABLE 3:

Diagnosis Performance Statistics on Artificial Intelligence (AI) and MRI for PI-RADS Category Thresholds: Peripheral Zone Lesions

PI-RADS Threshold for Performance Metric Evaluation	AI				MRI
	Overall	Reader Experience Level			Overall	Reader Experience Level
		Low	Moderate	High		Low	Moderate	High
PI-RADS ≥ 1
Sensitivity (%)	56.8 (51.3–63.1)	54.5 (46.5–63.0)	56.6 (48.7–63.0)	60.5 (54.0–68.1)	55.4 (49.9–61.7)	55.4 (47.9–63.1)	55.9 (49.1–63.5)	55.1 (47.9–63.7)
PPV (%)	52.1 (47.9–56.5)	54.1 (47.5–61.4)	47.7 (41.0–54.2)	54.6 (48.5–61.4)	58.7 (54.4–63.1)	59.1 (52.5–66.1)	51.6 (45.4–58.2)	65.3 (58.6–72.8)
PI-RADS ≥ 2
Sensitivity (%)	56.8 (51.3–63.1)	54.5 (46.5–63.0)	55.6 (48.7–63.0)	60.5 (54.0–68.1)	55.4 (49.9–61.7)	55.4 (47.9–63.1)	55.9 (49.1–63.5)	55.1 (47.9–63.7)
PPV (%)	52.5 (48.2–56.9)	54.1 (47.5–61.4)	48.3 (41.6–54.8)	55.0 (49.0–61.6)	59.3 (55.1–63.7)	61.0 (54.1–68.2)	51.6 (45.4–58.0)	65.3 (58.6–72.8)
PI-RADS ≥ 3
Sensitivity (%)	50.1 (44.2–57.1)	47.6 (39.7–56.5)	50.4 (43.2–58.4)	52.5 (44.9–61.5)	52.4 (47.2–58.7)	53.0 (45.8–60.8)	53.0 (46.0–61.0)	51.3 (44.1–60.4)
PPV (%)	60.4 (55.9–65.3)	60.7 (53.5–68.6)	54.1 (46.7–61.3)	66.6 (60.6–72.7)	63.4 (59.1–67.8)	66.1 (58.7–73.8)	52.2 (45.4–59.1)	71.9 (65.9–78.3)
PI-RADS ≥ 4
Sensitivity (%)	44.0 (38.4–50.7)	41.9 (34.8–50.0)	44.1 (36.9–52.2)	46.0 (39.9–54.3)	47.2 (41.6–53.5)	46.4 (38.5–54.7)	50.5 (43.5–58.7)	44.6 (38.2–53.2)
PPV (%)	67.5 (62.8–72.5)	64.2 (55.9–72.9)	59.5 (51.5–67.5)	78.8 (72.9–84.9)	67.8 (62.9–72.5)	68.6 (60.8–76.4)	55.1 (48.2–62.3)	79.5 (72.9–86.4)
PI-RADS ≥ 5
Sensitivity (%)	17.8 (13.4–22.8)	20.0 (13.9–26.5)	18.0 (12.0–25.0)	15.3 (10.2–21.7)	18.2 (13.6–23.4)	17.8 (11.6–24.6)	19.3 (13.3–26.7)	17.4 (11.7–24.5)
PPV (%)	88.6 (82.4–94.1)	90.8 (82.7–97.9)	83.1 (72.4–93.3)	91.9 (82.4–100)	84.7 (79.0–90.9)	84.3 (74.2–94.1)	83.5 (72.4–94.9)	86.4 (79.6–93.3)

Note—Values in parentheses are 95% CI. PI-RADS = Prostate Imaging Reporting and Data System, PPV = positive predictive value.