Table 1.
In vitro models of AKI in immortalized cells
| Cell Line | Markers | Function | Reference(s) |
|---|---|---|---|
| RPTEC/TERT1 | Aminopeptidase-N, E-cadherin, MRP2, MRP4, OAT4, MDR1, MATE1, OCTN2, OCT3 | Response to PTH treatment by increased cAMP levels GGT activity, Megalin/cubilin transport system | 168 , 169 |
| ciPTEC | Aminopeptidase-N, Pgp, AQP1, dpp-IV, MRP2/4,OCT2, OAT1, OAT3, BCRP, MATE1/2, CaSR, megalin/cubilin receptors | ALP activity, albumin endocytosis, sodium-dependent phosphate uptake, OCT2, and P-gp activity, UGT activity | 57 , 170 |
| HK-2 | Vimentin, cytokeratin, α3β1 integrin, leucine aminopeptidase, fibronectin, MCT1, MDR1, OATP4C1 | Gluconeogenesis, and Na+ -dependent glucose uptake, GGT and alkaline phosphatase activity, increased cAMP levels in response to PTH, synthesis and secretion of plasma proteins | 171 |
| Nki-2 | E-cadherin, CK8/18/19, GGT1, OAT1, OAT4 | Stable cell line, potentially valuable in toxicity and drug ???? | 172 |
| CIHP-1 | Synaptopodin, CD2AP, nephrin, podocin, ZO-1, P-cadherin, α, β, γ-catenin | A valuable tool in the study of human glomerular disease | 173 |
PTH, Parathyroid hormone; cAMP, Cyclic adenosine monophosphate; AQP1, aquaporin-1; ALP, Alkaline Phosphatase; UGT, Uridine 5'-diphospho-glucuronosyltransferase ; GGT, Gamma glutamyl-transferase.