Table 1.
Demographic and clinical characteristics of the entire cohort and stratified by quartiles of angiopoietin ratios
| Participant Characteristics | All (n=1503) | Quartiles of Angpt-1:Angpt-2 Ratio | P value | ||||
|---|---|---|---|---|---|---|---|
| Quartile 1: Range 0.01–0.76 pg/ml (n=375) | Quartile 2: Range 0.76–1.91 pg/ml (n=376) | Quartile 3: Range 1.92–4.14 pg/ml (n=376) | Quartile 4: Range 4.23–24.46 pg/ml (n=376) | ||||
| Age, yr | 65.8 (56.6–73.9) | 67.7 (57.4–75.8) | 66.5 (57.8–73.6) | 66.15 (58.1–73.8) | 63.7 (54.2–71.9) | <0.001 | |
| Female sex | 555 (37) | 118 (31) | 141 (38) | 145 (39) | 151 (40) | 0.073 | |
| Black race | 196 (13) | 42 (11) | 51 (14) | 55 (15) | 48 (13) | 0.558 | |
| Hispanic/Latino ethnicity | 37 (2) | 7 (2) | 13 (3) | 14 (4) | 3 (1) | 0.030 | |
| Current or former smoker | 862 (57) | 250 (67) | 217 (61) | 213 (56) | 182 (49) | <0.001 | |
| Preadmission COPD | 329 (22) | 87 (23) | 90 (24) | 62 (16) | 90 (24) | 0.100 | |
| Preadmission CVD | 680 (45) | 222 (59) | 175 (47) | 161 (43) | 122 (32) | <0.001 | |
| Preadmission CKD | 594 (40) | 175 (47) | 150 (40) | 161 (43) | 108 (29) | <0.001 | |
| Preadmission diabetes | 642 (43) | 179 (48) | 172 (46) | 154 (41) | 137 (36) | 0.008 | |
| Preadmission hypertension | 1118 (74) | 285 (76) | 285 (76) | 285 (76) | 263 (70) | 0.074 | |
| Preadmission heart failure | 319 (21) | 104 (28) | 97 (26) | 76 (20) | 42 (11) | <0.001 | |
| Variables at index hospitalization | |||||||
| Sepsis | 143 (10) | 42 (11) | 37 (10) | 36 (10) | 28 (7) | 0.369 | |
| UACR, mg/g | 32.0 (12.5–88.4) | 39.7 (16.6–103.3) | 37.7 (15.6–96.2) | 28.2 (10.5–98.6) | 21.0 (10–59.2) | <0.001 | |
| AKI | 746 (50) | 213 (57) | 199 (53) | 174 (46) | 160 (43) | <0.001 | |
| AKI stage | No AKI | 757 (50) | 162 (43) | 177 (47) | 202 (54) | 216 (57) | 0.013 |
| Stage 1 | 539 (36) | 151 (40) | 143 (38) | 128 (34) | 117 (31) | ||
| Stage 2 | 114 (8) | 32 (9) | 34 (9) | 27 (7) | 21 (6) | ||
| Stage 3 | 93 (6) | 30 (8) | 22 (6) | 19 (5) | 22 (6) | ||
| Creatinine, mg/dl | 1.4 (1.0–2.0) | 1.5 (1.2–2.2) | 1.4 (1.0–2.1) | 1.3 (1.0–1.9) | 1.2 (0.9–1.7) | <0.001 | |
| CRP, mg/L | 100 (30.2–197.6) | 113.7 (40.1–210.5) | 110.9 (35.1–206.4) | 82.7 (18.7–183.2) | 87.5 (25.0–167.4) | 0.002 | |
| NT-proBNP, pg/ml | 1191 (351–3157) | 2397 (973–4576) | 1364.5 (504–3345) | 995.5 (281–2718) | 568 (202–1486) | <0.001 | |
| Troponin, ng/ml | 31.6 (13.6–203.6) | 86.3 (22.2–359.4) | 39 (15.3–251.2) | 26.9 (13.0–134.6) | 17.9 (10.5–54.2) | <0.001 | |
| Variables at 3-month visit after hospitalization | |||||||
| BMI, kg/m2 | 29.7 (25.8–35) | 29.7 (26–35.2) | 29.9 (26.1–35.8) | 29.6 (25.2–35.4) | 29.6 (25.9–34.1) | 0.607 | |
| UACR, mg/g | 14.4 (6.7–59.3) | 20 (8.3–110.1) | 18.3 (8.1–89.7) | 12.2 (6.25–44.1) | 10.0 (5.4–27.8) | <0.001 | |
| Creatinine, mg/dl | 1.0 (0.8–1.3) | 1.2 (0.9–1.5) | 1.0 (0.9–1.4) | 1.0 (0.9–1.3) | 1.0 (0.8–1.2) | <0.001 | |
| eGFR, ml/min per 1.73 m2 | 68.2 (50.2–89.1) | 60.2 (44.1–82.6) | 67.1 (49.6–89.4) | 68.1 (51.6–87.4) | 77.6 (60.1–93.1) | <0.001 | |
| CRP, mg/L | 3.6 (1.5–7.6) | 4.6 (2.2–9.8) | 3.6 (1.7–7.4) | 3.1 (1.2–7.3) | 3.2 (1.2–7) | <0.001 | |
| NT-proBNP, pg/ml | 290 (88–902) | 643 (217.5–1997) | 390 (114.5–1031.5) | 250 (96–708) | 125 (45–329) | <0.001 | |
| Troponin, ng/ml | 16.9 (10.4–28.7) | 20.8 (13.2–36.8) | 18.9 (10.9–30.1) | 16.8 (10.5–26.3) | 12.4 (7.9–20.8) | <0.001 | |
Results are presented as median (IQR) or count (percentage). At baseline, there were 12 participants with missing smoking status, 4 with missing COPD status, 3 with missing CVD status, 2 with missing hypertension status, 1 with missing heart failure status, 10 with missing UACR values, 59 with missing CRP values, 18 with missing NT-proBNP values, and 61 with missing troponin values. At 3 months, there were 2 patients with missing BMI values, 2 with missing UACR values, 22 with missing CRP values, 65 with missing NT-proBNP values, and 70 with missing troponin values.