Table 4.
Reclassification of events and nonevents in the CRIC study
| Model Comparisonsa | Proportion of Participants Correctly Reclassifiedb | Net Reclassification Index (95% CI) | |
|---|---|---|---|
| Events Reclassified, % (95% CI) | Nonevents Reclassified, % (95% CI) | ||
| Comparing with ACC/AHA PCEs | |||
| Model 1 versus ACC/AHA PCEs | −10.0 (−2.5 to −16.5) | 1.5 (−0.9 to 3.9) | −8.5 (−1.0 to −15.3) |
| Model 2 versus ACC/AHA PCEs | −4.8 (−12.2 to 2.8) | 6.6 (3.7 to 9.6) | 1.8 (−6.2 to 10.0) |
| Model 3 versus ACC/AHA PCEs | −1.4 (−8.9 to 6.4) | 10.0 (6.8 to 13.3) | 8.6 (0.2 to 16.6) |
| Comparing with model 1 | |||
| Model 2 versus 1 | 6.7 (−0.3 to 13.5) | 5.2 (2.8 to 8.0) | 11.9 (4.6 to 18.9) |
| Model 3 versus 1 | 11.7 (3.6 to 19.4) | 8.7 (5.9 to 11.7) | 20.4 (12.3 to 28.6) |
| Comparing with model 2 | |||
| Model 3 versus 2 | 5.8 (−0.1 to 11.2) | 3.7 (1.4 to 6.0) | 9.5 (3.3 to 15.3) |
a
Model 1 indicates the ACC/AHA PCEs variables recalculated in the CRIC study; model 2 indicates the CRIC clinical model; and model 3 indicates the CRIC enriched model.
b
Models are compared for reclassification of events to a higher predicted risk category and nonevents to a lower predicted risk category, using cut points of 7.5% and 20%. More detailed information can be found in Supplemental Tables 7 and 8.