Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Oct 21;1(2):161–167. doi: 10.1097/BS9.0000000000000031

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 The Authors. Published by Wolters Kluwer Health Inc., on behalf of the Chinese Association for Blood Sciences.

This is an-open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0

PMC Copyright notice

The association between lncRNA PCED1B-AS1 and chromatin accessibility during erythroid differentiation. (A) Dynamic profile of chromatin accessibility and histone modification of H3K27ac around PCED1B-AS1 loci during erythroid differentiation. (B) Confirmation of physical binding of GATA1 around PCED1B-AS1 loci by ChIP-qPCR in K562 cells. Rank1 and Rank2 are from the red box on the left side in (A) picture, and Rank3 and Rank4 are from the red box on the right side in (A). The bar graphs represent the average of percentage input (mean ± SD) from three independent ChIP experiments. (C) Known motif identification of peaks within 20 kb of PCED1B-AS1. (D) Regulation factors of PCED1B-AS1 within its 100 kb genomic regions in EB. (E) Relative expression of PCED1B-AS1 in TF-1 cells with GATA1 knockdown by siRNA. (F) Correlation between PCED1B-AS1 with its potential target genes. (G) Model of PCED1B-AS1 participates in erythroid differentiation via dynamic chromatin remodeling involving GATA1.