Table 2.
Comparison of the conversion of C, 5mC, 5hmC in different DNA methylation profiling methods.
| Base | WGBS | TAPS | TAPSβ | EM-seq | ACE-seq | TAB-seq | oxBS-seq |
|---|---|---|---|---|---|---|---|
| C | T | C | C | T | T | T | T |
| 5mC | C | T | T | C | T | T | C |
| 5hmC | C | T | C | C | C | C | T |
ACE-seq = APOBEC-coupled epigenetic sequencing, EM-seq = Enzymatic Methyl-seq, oxBS-seq = oxidative bisulfite sequencing, TAB-seq = Tet-assisted bisulfite sequencing, TAPS = TET-assisted pyridine borane sequencing, TAPSβ = TAPS with β-glucosyltransferase (β-GT) blocking, WGBS = whole-genome bisulfite sequencing.