Table 1. Details of the prognostication scores included in the present study.
| Prognostication score | Predicted outcome | Components of score | Population used for development | Discriminatory ability in the original publication |
|---|---|---|---|---|
| OHCA score [5] | CPC 3–5 at hospital discharge | First monitored rhythm; no-flow duration; low-flow duration; creatinine; lactate | 130 adult OHCA survivors admitted to a French ICU between 1999 and 2003 | Derivation cohort: AUC 0.82 (95% CI, 0.70–0.95) Validation cohort: AUC 0.88 (95% CI, 0.82–0.94) |
| CAHP score [6] | CPC 3–5 at hospital discharge | Age; location of cardiac arrest; first monitored rhythm; no-flow duration; low-flow duration; pH; epinephrine dose | 819 OHCA survivors in a multicenter registry in Paris and suburbs between 2011 and 2012 | Derivation cohort: AUC 0.93 (95% CI, 0.91–0.95) Validation cohort: AUC 0.85 (95% CI, 0.82–0.91), AUC 0.91 (95% CI, 0.88–0.93) |
| PROLOGUE [7] | CPC 3–5 at hospital discharge | Presence of a witness on collapse; potassium; lactate; epinephrine dose; low-flow duration; hemoglobin; creatinine; phosphate; first monitored rhythm; pupillary light reflex; age; GCS motor score | 671 adult cardiac arrest survivors admitted to a university hospital in South Korea between 2014 and 2016 | Derivation cohort: AUC 0.940 (95% CI, 0.923–0.956) Internal validation: AUC 0.930 (95% CI, 0.912–0.949) Validation cohort: AUC 0.942 (95% CI, 0.917–0.968) |
| C-GRApH score [8] | CPC 1–2 at hospital discharge | Pre-existing coronary artery disease; glucose; first monitored rhythm; age; pH | 122 adult OHCA survivors treated with TTM at a hospital in the USA between 2008 and 2012 | Derivation cohort: c-statistic 0.818 (95% CI, 0.737–0.899) Validation cohort: c-statistic 0.814 (95% CI, 0.759–0.869) |
| TTM risk score [9] | CPC 3–5 at 6 months after OHCA | Age; location of cardiac arrest; first monitored rhythm; no-flow duration; low-flow duration; epinephrine dose; GCS motor score; PaCO2 | 933 OHCA survivors included in the TTM trial | Derivation cohort: AUC 0.842 (95% CI, 0.840–0.845) Internal validation: AUC 0.818 (95% CI, 0.816–0.821) |
| Prediction score by Aschauer et al. [10] | Survival at 30 days after OHCA | Time to ROSC; age; first monitored rhythm; epinephrine dose | 1,242 OHCA survivors admitted to a university hospital in Austria between 2000 and 2012 | Validation cohort: AUC 0.810 |
| 5-R score [11] | CPC 1–2 at hospital discharge | No-flow duration; first monitored rhythm; time to ROSC; rearrest; pupillary light reflex | 66 OHCA survivors treated with TTM at a hospital in Japan between 2006 and 2011 | Derivation cohort: AUC 0.95 (95% CI, 0.89–10) |
| NULL-PLEASE score [12] | In-hospital mortality | First monitored rhythm; presence of a witness on collapse; bystander CPR; low-flow duration; pH; lactate; pre-existing chronic kidney disease; age; circulatory status on emergency department arrival; etiology of cardiac arrest | 56 OHCA survivors admitted to an ICU in the UK | AUC: not available No patient with a NULL-PLEASE score of > 6 survived to hospital discharge |
| SR-QOLl score [13] | Survival at 1 year after hospital discharge | Bystander CPR; first monitored rhythm; presence of a witness on collapse; no-flow duration; etiology of cardiac arrest; age | 591 adult patients who experienced OHCA in four Serbian cities between 2007 and 2008 | Derivation cohort: AUC 0.913 ± 0.026 |
| Cardiac arrest survival score [14] | In-hospital mortality | Age; presence of a witness on collapse; location of cardiac arrest; bystander CPR; first monitored rhythm | 2,685 adult OHCA survivors included in a large metropolitan cardiac arrest registry in USA between 2007 and 2015 | Derivation cohort: AUC 0.7172 Validation cohort: AUC 0.7081 |
| rCAST score [15] | CPC 3–5 at 30 and 90 days after OHCA | First monitored rhythm; presence of a witness on collapse; time to ROSC; pH; lactate; GCS motor score | 460 adult OHCA survivors who were treated with TTM and were included in a multicenter registry in Japan between 2014 and 2015 | Derivation cohort: AUC 0.892 and 0.895 for CPC 3–5 at 30 and 90 days after OHCA, respectively |
| PHR risk score [16] | In-hospital mortality | Age; no-flow duration; time to ROSC; location of cardiac arrest (out-of-hospital versus in-hospital); presence of a witness on collapse; first monitored rhythm | 376 cardiac arrest survivors who were treated with TTM and included in a Polish multicenter registry between 2012 and 2016 | Derivation cohort: AUC 0.742 |
OHCA, out-of-hospital cardiac arrest; CPC, cerebral performance category; ICU, intensive care unit; AUC, area under the receiver operating characteristic curve; CI, confidence interval; CAHP, cardiac arrest hospital prognosis; PROLOGUE, PROgnostication using LOGistic regression model for Unselected adult cardiac arrest patients in the Early stages; TTM, targeted temperature management; GCS, Glasgow Coma Scale; PaCO2, partial pressure of arterial carbon dioxide; ROSC, restoration of spontaneous circulation; CPR, cardiopulmonary resuscitation; SR-QOLl, Serbian quality of life long-term; rCAST, revised post-cardiac arrest syndrome for therapeutic hypothermia; PHR, Polish hypothermia registry.