Table 3. Performances of cardiac arrest-specific prognostication scores in predicting poor outcome at 6 months after cardiac arrest.
| Prediction score | AUC (95% CI) | P value | SEN (95% CI) | SPE (95% CI) | PPV (95% CI) | NPV (95% CI) | ACC (95% CI) | Cut-off |
|---|---|---|---|---|---|---|---|---|
| PROLOGUE | 0.923 (0.904–0.941) | <0.001 | 82.6 (79.5–85.7) | 87.1 (82.9–91.4) | 93.8 (91.6–95.9) | 68.2 (63.0–73.4) | 84.0 (81.4–86.5) | 0.752 |
| TTM risk score | 0.913 (0.892–0.935) | <0.001 | 90.8 (88.4–93.2) | 73.9 (68.3–79.4) | 89.0 (86.5–91.6) | 77.4 (72.0–82.8) | 85.7 (83.3–88.1) | 13 |
| CAHP score | 0.906 (0.884–0.929) | <0.001 | 85.8 (82.9–88.7) | 82.6 (77.8–87.4) | 92.0 (89.7–94.3) | 71.3 (66.0–76.6) | 84.8 (82.3–87.3) | 156.92 |
| Prediction score by Aschauer et al. | 0.892 (0.867–0.917) | <0.001 | 88.3 (85.6–90.9) | 74.3 (68.8–79.8) | 88.9 (86.3–91.5) | 73.1 (67.5–78.6) | 84.1 (81.6–86.6) | 20 |
| NULL-PLEASE score | 0.886 (0.861–0.910) | <0.001 | 91.8 (89.6–94.1) | 65.1 (59.1–71.2) | 86.0 (83.3–88.8) | 77.3 (71.6–83.1) | 83.8 (81.3–86.4) | 5 |
| 5-R score | 0.879 (0.855–0.903) | <0.001 | 75.1 (71.6–78.7) | 82.6 (77.8–87.4) | 91.0 (88.4–93.6) | 58.7 (53.5–63.9) | 77.4 (74.5–80.3) | 4 |
| rCAST score | 0.867 (0.840–0.894) | <0.001 | 80.3 (77.0–83.6) | 81.3 (76.4–86.2) | 90.9 (88.4–93.5) | 63.8 (58.5–69.2) | 80.6 (77.9–83.3) | 10.0 |
| PHR risk score | 0.865 (0.838–0.893) | <0.001 | 77.4 (74.0–80.9) | 81.7 (76.9–86.6) | 90.8 (88.3–93.4) | 60.8 (55.5–66.1) | 78.7 (75.9–81.6) | 7.59 |
| OHCA score | 0.844 (0.815–0.872) | <0.001 | 72.1 (68.4–75.8) | 84.2 (79.6–88.8) | 91.4 (88.8–94.0) | 56.4 (51.3–61.5) | 75.7 (72.8–78.7) | 33.98 |
| Cardiac arrest survival score | 0.831 (0.799–0.862) | <0.001 | 83.8 (80.8–86.9) | 75.9 (70.5–81.3) | 89.1 (86.4–91.7) | 66.8 (61.2–72.4) | 81.5 (78.8–84.2) | 7.0 |
| C-GRApH score | 0.771 (0.737–0.805) | <0.001 | 93.6 (91.6–95.6) | 36.1 (30.0–42.2) | 77.4 (74.2–80.5) | 70.7 (62.7–78.8) | 76.4 (73.4–79.3) | 3 |
| SR-QOLl score | 0.749 (0.711–0.786) | <0.001 | 92.4 (90.2–94.6) | 48.1(41.8–54.4) | 80.6 (77.6–83.7) | 73.0 (66.1–79.9) | 79.1 (76.3–81.9) | 50 |
This analysis only included 804 patients for whom all of the 12 prognostication scores were available. The cut-off for PROLOGUE indicates a cut-off point of the poor outcome probability predicted using PROLOGUE. AUC, area under the receiver operating characteristic curve; CI, confidence interval; SEN, sensitivity; SPE, specificity; PPV, positive predictive value; NPV, negative predictive value; ACC, accuracy; PROLOGUE, PROgnostication using LOGistic regression model for Unselected adult cardiac arrest patients in the Early stages; TTM, targeted temperature management; CAHP, cardiac arrest hospital prognosis; rCAST, revised post-cardiac arrest syndrome for therapeutic hypothermia; PHR, Polish hypothermia registry; OHCA, out-of-hospital cardiac arrest; SR-QOLl, Serbian quality of life long-term.