Table 4. Performances of cardiac arrest-specific prognostication scores in predicting poor outcome at 6 months after cardiac arrest after multiple imputation.
| Prediction score | AUC (95% CI) | P value | SEN (95% CI) | SPE (95% CI) | PPV (95% CI) | NPV (95% CI) | ACC (95% CI) | Cut-off |
|---|---|---|---|---|---|---|---|---|
| PROLOGUE | 0.906 (0.888–0.924) | <0.001 | 80.8 (78.0–83.5) | 85.7 (82.1–89.3) | 92.7 (90.8–94.7) | 66.4 (62.1–70.7) | 82.3 (80.1–84.5) | 0.752 |
| TTM risk score | 0.903 (0.884–0.922) | <0.001 | 89.8 (87.7–91.9) | 73.1 (68.5–77.7) | 88.3 (86.1–90.5) | 76.1 (71.6–80.6) | 84.7 (82.6–86.8) | 13 |
| CAHP score | 0.890 (0.869–0.910) | <0.001 | 81.8 (79.1–84.4) | 82.4 (78.4–86.3) | 91.3 (89.2–93.3) | 66.7 (62.3–71.1) | 81.9 (79.7–84.2) | 162.66 |
| Prediction score by Aschauer et al. | 0.885 (0.863–0.906) | <0.001 | 88.5 (86.3–90.7) | 72.8 (68.2–77.4) | 88.0 (85.8–90.3) | 73.7 (69.1–78.2) | 83.7 (81.5–85.8) | 20 |
| NULL-PLEASE score | 0.869 (0.847–0.891) | <0.001 | 90.8 (88.8–92.8) | 62.5 (57.4–67.5) | 84.5 (82.1–86.9) | 75.1 (70.2–80.0) | 82.1 (79.9–84.3) | 5 |
| 5-R score | 0.873 (0.853–0.894) | <0.001 | 75.4 (72.5–78.4) | 82.1 (78.1–86.1) | 90.5 (88.3–92.7) | 59.7 (55.3–64.0) | 77.5 (75.1–77.9) | 4 |
| rCAST score | 0.846 (0.822–0.871) | <0.001 | 77.7 (74.8–80.5) | 79.6 (75.4–83.7) | 89.6 (87.3–91.8) | 61.2 (56.8–65.6) | 78.2 (75.9–80.6) | 10.0 |
| PHR risk score | 0.857 (0.833–0.880) | <0.001 | 75.9 (73.0–78.9) | 80.1 (76.0–84.3) | 89.6 (87.3–91.9) | 59.6 (55.2–64.0) | 77.2 (74.8–79.6) | 7.59 |
| OHCA score | 0.831 (0.806–0.855) | <0.001 | 71.7 (68.6–74.8) | 82.4 (78.4–86.3) | 90.2 (87.9–92.5) | 56.3 (52.1–60.6) | 75.0 (72.5–77.5) | 33.67 |
| Cardiac arrest survival score | 0.817 (0.790–0.844) | <0.001 | 82.6 (80.0–85.2) | 74.8 (70.3–79.3) | 88.1 (85.8–90.4) | 65.6 (61.0–70.2) | 80.2 (77.9–82.5) | 7.0 |
| C-GRApH score | 0.755 (0.725–0.784) | <0.001 | 93.4 (91.7–95.1) | 35.3 (30.3–40.3) | 76.5 (73.9–79.2) | 70.4 (63.7–77.1) | 75.6 (73.1–78.0) | 3 |
| SR-QOLl score | 0.730 (0.698–0.761) | <0.001 | 91.2 (89.2–93.1) | 46.2 (41.0–51.4) | 79.3 (76.7–81.9) | 69.9 (64.1–75.8) | 77.4 (75.0–79.8) | 46.0 |
The cut-off for PROLOGUE indicates a cut-off point of the poor outcome probability predicted using PROLOGUE. AUC, area under the receiver operating characteristic curve; CI, confidence interval; SEN, sensitivity; SPE, specificity; PPV, positive predictive value; NPV, negative predictive value; ACC, accuracy; PROLOGUE, PROgnostication using LOGistic regression model for Unselected adult cardiac arrest patients in the Early stages; TTM, targeted temperature management; CAHP, cardiac arrest hospital prognosis; rCAST, revised post-cardiac arrest syndrome for therapeutic hypothermia; PHR, Polish hypothermia registry; OHCA, out-of-hospital cardiac arrest; SR-QOLl, Serbian quality of life long-term.