TABLE 1.

Schedule of enrollment, interventions, and assessments.

Timepoint	Study period
	Enrollment	Allocation	Post-allocation				Close-out
	Anesthesia clinic visit	Prior to sedation	During sedation	Sedation emergence	15 min in recovery room	30 min in recovery room	Hospital discharge
Enrollment	—	—	—	—	—	—	—
Eligibility criteria	×	—	—	—	—	—	—
Written informed consent	×	—	—	—	—	—	—
Demographic data	×	—	—	—	—	—	—
Baseline characteristics	×	—	—	—	—	—	—
Randomization	—	×	—	—	—	—	—
Allocation	—	×	—	—	—	—	—
Interventions	—		—	—	—	—	—
Ciprofol and esketamine	—	×	—	—	—	—	—
Propofol and esketamine	—	×	—	—	—	—	—
Ciprofol and placebo	—	×	—	—	—	—	—
Propofol and placebo	—	×	—	—	—	—	—
Assessments	—	—	—	—	—	—	—
Desaturation events	—	—	×	×	×	×	×
Hypotension events	—	—	×	×	×	×	×
Severe desaturation	—	—	×	×	×	×	×
Severe hypotension	—	—	×	×	×	×	×
Bradycardia	—	—	×	×	×	×	×
Nausea and vomiting	—	—	—	×	×	×	×
Dizziness or headache	—	—	—	×	×	×	×
Hallucination or nightmare	—	—	—	×	×	×	×
Injection pain	—	—	×	—	—	—	—
VAS pain scores	—	—	—	×	×	×	—
VAS fatigue scores	—	—	—	×	×	×
Endoscopist satisfaction	—	—	×	—	—	—	—
Patient satisfaction	—	—	—	—	—	—	×

According to SPIRIT, 2013 statement of defining standard protocol items for clinical trials.

VAS, visual analog scale.