Table 1.
Analysis of HFNCOT Devices and Settings
| Study | Population | Device | Initial Flow | Initial FiO2 | Temperature |
|---|---|---|---|---|---|
| Frat et al. (11) | RR > 25 PaO2/FiO2 < 300 PaCO2 <45 mmHg (O2 ≥ 10 L/min) | Optiflow® | 50 L/min | 100% (SpO2 > 92%) |
37°C |
| Roca et al. (12) | SpO2 < 96%(FiO2 ≥ 50%) | Optiflow® | 20-30 L/min | Previous | No data |
| Schwablaeur et al. (13) | PaO2 < 55 mmHg(FiO2 21%) | Optiflow® | 55 L/min | 50% | No data |
| Parke et al. (14) | Mild-moderate hypoxemic ARF | Optiflow® | 35 L/min | No data (SpO2 ≥ 95%) |
No data |
| Cho et al. (15) | PaO2/FiO2 < 300RR > 24(O2 > 8 L/min) | Optiflow® | 30-40 L/min | 40-100% (SpO2 > 92% and PaO2 > 65 mmHg) |
No data |
| Sztrymf et al. (16) | SpO2 < 96%RR ≥ 25(FiO2 > 50%) | Optiflow® | No data (median 40 L/min) |
No data | No data |
| Jones et al.(17) | SpO2 ≤ 92% RR ≥ 22 | Airvo-1®Airvo-2® | 40 L/min | 28% | 37°C |
| Nagata et al. (18) | Neoplasia and need for any respiratory support | Optiflow® | 35-45 L/min | (SpO2 ≥ 95%) | No data |
| Lamiale et al. (19) | Immunosuppressed O2 > 6 L/min for SpO2 > 95 %RR > 30;respiratory distress |
No data | 40-50 L/min | 100% (SpO2 > 90%) |
No data |
| Roca et al. (20) | Lung transplant SpO2 ≤ 95%RR ≥ 25(FiO2 ≥ 50%) |
Optiflow® | No data | No data (SpO2 95%) |
37°C |
| Peters et al. (21) | Do-not-intubate status |
Optiflow® | 35 L/min (increased to 45-50 L/min) |
Previous (SpO2 > 90%) |
No data |
| Frat (22) | ARDS | Optiflow® | 50 L/min | 100% (SpO2 > 92%) |
37°C |
| Sztrymf et al. (3) | O2 > 9 L/min for SpO2 > 92%RR > 24;Respiratory distress | Optiflow® | No data | No data | 37°C |
| Rittayamai et al. (23) | SpO2 < 94%RR > 24 | Optiflow® | 35 L/min | No data (SpO2 ≥ 94%) |
37°C |
| Lenglet et al. (24) | O2 > 9 L/minRespiratory distress | Optiflow® | 40 L/min | ≥ 60% | No data |
| Rello et al. (25) | Influenza A H1N1 SpO2 ≤ 92%(O2 > 9 L/min) |
Optiflow® | 30 L/min | 100% (SpO2 95%) |
37°C |
| Messika et al. (26) | ARDS | Optiflow® | 60 /min | 100% * | 37°C |
| Coudroy et al. (27) | PaO2/FiO2 < 300RR > 24Respiratory distress | Optiflow® | 50 L/min | 60% | No data |
| Raesi et al. (28) | Moderate-severe asthma exacerbation | No data | 15-35 L/min | No data | 37°C |
*The majority of the patients.
ARDS, acute respiratory distress syndrome; FiO2, fraction of inspired oxygen; PaO2, partial pressure of oxygen; RR, respiratory rate; SpO2, peripheral capillary oxygen saturation.