Table 1.
The Demographic and Clinical Characteristics of Patients With IBD According to MEFV Mutation Carriage
| Patients With MEFV Mutations (n = 250) | Patients Without MEFV Mutations (n = 347) | P | |
|---|---|---|---|
| Age (years; median) | 10.5 ± 4.9 | 10.5 ± 4.7 | .81 |
| Gender (male/female) | 131/119 | 164/183 | .21 |
| IBD type (n) | |||
| UC | 131 (52.4%) | 203 (58.5%) | .23 |
| CD | 99 (39.6%) | 125 (36%) | |
| IC | 20 ( 8%) | 19 (5.5%) | |
| Median PCDAI (median, range) | 38.5 ± 18.9 | 40.5 ± 16 | .24 |
| Median PUCAI (median, range) | 43.1 ± 19.8 | 49.4 ± 18.8 | .007 |
| Extraintestinal disease | 58 (24%) | 42 (12.5%) | .001 |
| Perianal disease | 60 (24%) | 93 (26.8%) | .20 |
| MEFV mutations | |||
| Homozygous mutation | 50 (25.5%) | ||
| Heterozygous mutation | 146 (74.5%) | ||
| Not mentioned | 23 (2.5%) |
IBD, inflammatory bowel disease; MEFV, Mediterranean fever gene; PCDAI, pediatric Crohn’s disease activity index; PUCAI, pediatric ulcerative colitis activity index.
P < .05 is statistically significant.