TABLE 1.
Mean pharmacokinetic parameters of SCH 56592 in mice, rats, dogs, and cynomolgus monkeysa
| Species (n) | Parameter | i.v. in HPβCD | p.o. in HPβCD | p.o. in MC |
|---|---|---|---|---|
| Mouse (3) | Cmax (μg/ml) | 7.8 (13) | 6.3 (11) | |
| Tmax (h) | 2.0 | 1.0 | ||
| AUC0–∞ (μg · h/ml) | 137.0 | 143.0 | 63.7 | |
| t1/2 (h) | 7.0 | |||
| Bioavailability (%) | 104.0 | 46.5 | ||
| Rat (3) | Cmax (μg/ml) | 3.5 (13) | 3.0 (20) | |
| Tmax (h) | 2.0 | 4.0 | ||
| AUC0–∞ (μg · h/ml) | 89.4 | 58.6 | 43.0 | |
| t1/2 (h) | 7.0 | |||
| Bioavailability (%) | 65.6 | 48.0 | ||
| Dog (2) | Cmax (μg/ml) | 3.5 | 3.0 | |
| Tmax (h) | 2.0 | 4.0 | ||
| AUC0–∞ (μg · h/ml) | 89.4 | 58.6 | 43.0 | |
| t1/2 (h) | 7.0 | |||
| Bioavailability (%) | 65.6 | 48.0 | ||
| Monkey (2) | Cmax (μg/ml) | 1.1 | 0.4 (18)b | |
| Tmax (h) | 14.0 | 5.0 (31) | ||
| AUC0–∞ (μg · h/ml) | 115.0 | 59.4 | 15.9 (20) | |
| t1/2 (h) | 22.7 | |||
| Bioavailability (%) | 51.7 | 13.8 |
a
Values in parentheses are CVs (in percent).
b
n = 6.