TABLE 2.
Mean pharmacokinetic parameters of SCH 56592 following p.o. administration in MC suspensions
| Species (n) | Dose (mg/kg) | Cmax (μg/ml) | Tmax (h) | AUC0–∞ (μg · h/ml) |
|---|---|---|---|---|
| Mice (6) | 20 | 4.9 (20)a | 3.0 | 82.0 |
| 40 | 11.5 (45) | 7.0 | 146.0 | |
| 80 | 12.1 (20) | 7.0 | 363.0 | |
| 160 | 17.1 (14) | 12.0 | 508.0 | |
| Rats (3) | 10 | 2.7 (51) | 4.0 | 31.4 |
| 20 | 3.7 (12) | 6.0 | 65.1 | |
| 40 | 6.0 (19) | 4.0 | 119.0 | |
| 80 | 10.2 (26) | 6.0 | 189.9 | |
| 120 | 10.1 (11) | 4.0 | 262.6 | |
| Rabbits (6) | 20 | 4.2 (12) | 5.1 (21) | 77.5 (16) |
| Dogs (fasting) (5) | 10 | 0.2 (22) | 7.6 (121) | 7.5 (45) |
| Dogs (fed) (6) | 10 | 0.7 (28) | 8.3 (93) | 26.6 (42) |
| 40 | 2.1 (31) | 9.2 (90) | 105.0 (30) | |
| 80 | 3.1 (20) | 9.0 (82) | 167.0 (18) | |
| 120 | 3.3 (27) | 15.0 (66) | 192.0 (34) |
a
Values in parentheses are CVs (in percent).