Table 1.
Comparison of FGF-19 with Other Parameters and Patient’s Characteristics
| IBD Active | IBD in Remission | IBD After Surgery | IBS-D | MC | Healthy Subjects | |
|---|---|---|---|---|---|---|
| Number of patients, n (%) | 21 (18) | 21 (18) | 21 (18) | 23 (20) | 14 (13) | 14 (13) |
| Gender, female (%) | 13 (62) | 9 (43) | 9 (43) | 13 (57) | 11 (78) | 5 (45) |
| Age, Mean ± SD | 45 ± 13 | 50 ± 15 | 48 ± 17 | 46 ± 15 | 60 ± 17 | 41 ± 17 |
| CDAI, Mean ± SD,Median (IQR) | 338 ± 74345 (220-440) | 107 ± 47130 (30-150) | 257 ± 126260 (100-410) | - | - | - |
| Mayo score (full), Mean ± SD,Median (IQR) | 7.9 ± 2.68.5 (4-11 ) | 1.3 ± 0.71.5 (0-2 ) | 7.7 ± 2.77.5 (5-11) | - | - | - |
| Endoscopic Mayo score, Mean ± SD | 2.2 ± 0.5 | 0.4 ± 0.5 | 2 ± 0.816 | - | - | - |
| Stool Index (SI) Mean ± SD, Median (IQR) | 49 ± 2146.5 (15-84) | 33 ± 1335 (6-54) | 58 ± 2360 (18-98) | 31 ± 1824 (12-84) | 63 ± 2570 (18-91) | 6 ± 34 (3-12) |
| Stool frequency per day, mean ± SD,Median (IQR) | 7.8 ± 38.5 (3-13) | 5.8 ± 26 (2-9) | 9 ± 39 (3-15) | 4.6 ± 24 (3-12) | 9.2 ± 310 (3-13) | 1.3 ± 11 (1-3) |
| Duration of the diarrhea (weeks), Median (25th-75th percent) |
5 (4-6) | 4 (4-5) | 6 (4-7) | 5 (5-6) | 6 (6-15) | 0(0) |
| Night defecation, n (%) | 16 (76) | 4 (19) | 10 (47) | 2 (8.7) | 9 (64) | 0 (0) |
| Diarrhea appear during fasting, n (%) | 12 (57) | 5 (23) | 11 (52) | 5 (21) | 6 (42.9) | 0 (0) |
| ROME IV, n (%) | 9.5 (43) | 2 (9.5) | 6 (28.6) | 23 (100) | 10 (71.4) | 0(0) |
| CRP, Mean ± SD,Median (IQR), mg/dL | 1.2 ± 2.40.4 (0.1-12) | 0.3 ± 0.20.3 (0.2-0.9) | 0.4 ± 0.30.4 (0.2-1.3) | 0.1 ± 0.10.1(0.1-0.5) | 0.5 ± 0.30.3(0.1-1.4) | 0.3 ± 0.20.2(0.1-0.9) |
| Fecal calprotectin, Mean ± SD,Median (IQR), µg/g | 750.9 ± 465.9806 (78-1800) | 81.3 ± 39.785 (10-185) | 375 ± 264.5338 (25-813) | 47.5 ± 38.130 (5-125) | 221 ± 279115 (44-100) | 43 ± 2330 (18-82) |
| Total free fecal bile acids, Mean ± SD,Median (IQR), µmol/g | 42 ± 19.438 (6.7-85.2) | 37.5 ± 14.137 (5.6-78) | 40.1 ± 20.938 (6.8-96) | 40.8 ± 20.337 (12-97) | 40.6 ± 25.438 (6-96) | 44 ± 13.338 (32-72) |
| FGF-19, Median (25-75th percentile) pg/mL |
0.009 (0.005-211) |
0.009 (0.005-78) |
0.005 (0.002-0.012) |
266 (78-831) |
0.010 (0.004-78) |
463 (50-858) |
IQR, interquartile ranges; CRP, C-reactive protein; IBD, inflammatory bowel disease; FGF-19, fibroblast growth factor-19; SD, standard deviation.