Table 2. Mendelian randomization results for inverse variance weighted, weighted median, weighted mode, and MR-Egger methods.

Direction	Vigorous physical activity → BMI				Moderate physical activity → BMI				Sedentary time → BMI
MR method	beta	SE	p-value	N SNPs	beta	SE	p-value	N SNPs	beta	SE	p-value	N SNPs
IVW	–0.17	0.08	0.04	5	–0.24	0.12	0.05	3	0.11	0.08	0.16	5
Weighted median	–0.18	0.10	0.08	5	–0.18	0.12	0.13	3	0.10	0.10	0.29	5
Weighted mode	–0.19	0.12	0.19	5	–0.14	0.15	0.43	3	0.08	0.14	0.59	5
MR-Egger	1.33	2.21	0.59	5	0.12	0.45	0.84	3	0.49	0.36	0.26	5
Direction	BMI → Vigorous physical activity				BMI → Moderate physical activity				BMI → Sedentary time
IVW	–0.07	0.02	0.01	57	–0.06	0.03	0.03	55	0.07	0.03	0.01	57
Weighted mode	–0.01	0.06	0.83	57	0.02	0.06	0.68	55	–0.06	0.08	0.46	57
Weighted median	–0.04	0.03	0.27	57	0.003	0.04	0.93	55	0.03	0.04	0.48	57
MR-Egger	0.13	0.07	0.06	57	0.16	0.07	0.04	55	–0.02	0.08	0.76	57
BMI, Body mass index (BMI); SE, standard error; N SNPs, number of single nucleotide polymorphism; IVW, inverse variance weighted; CI, 95% confidence interval.

The results display the data according to the goodness-of-fit for the causal or the sharing model. The median q value indicates the proportion of variants with correlated pleiotropy. CI, confidence interval; PA, physical activity; BMI, body mass index; P, P-value.