Table 2.

Relationship of APACHE II Score, MRC-ICU Score, and Patient Outcomes

	APACHE II Score				MRC-ICU Score
Variable	Correlation Coefficienta	P Value	βb	P Value	Correlation coefficienta	P Value	βb	P Value
Pharmacist interventions
At 24 hours	0.283	0.004	0.031	0.085	0.370	<0.001	0.099	0.001
At 48 hours	0.325	0.008	0.037	0.164	0.280	0.023	0.112	0.013
At ICU discharge	0.366	<0.001	0.156	0.001	0.479	<0.001	0.323	<0.001
Drug-drug interactions
Class B	–0.168	0.243	–0.033	0.607	0.318	0.024	0.312	0.013
Class C	–0.023	0.875	–0.187	0.461	0.383	0.006	1.528	0.002
Class D	–0.331	0.019	–0.358	0.091	0.427	0.002	1.392	0.001
Class X	0.097	0.502	0.025	0.483	0.067	0.646	0.091	0.197
Total	–0.192	0.181	–0.585	0.216	0.452	0.001	3.264	<0.001

Abbreviations: APACHE II, Acute Physiology and Chronic Health Evaluation II; ICU, intensive care unit; MRC-ICU, medication regimen complexity–intensive care unit.

^aSpearman rank-order correlation.

^bCalculated via multiple linear regression adjusting for age, gender, and admission type (medical vs surgical)