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. 2022 Apr 2;86:101803. doi: 10.1016/j.cimid.2022.101803

Table 2.

Percentage of seroconversion (with confidence intervals) for Leptospira serogroups Canicola, Icterohaemorrhagiae, Grippotyphosa and Pomona after two administrations of the vaccines at D0 and D21. Group A and B were administered Recombitek®C8 alone on D0 and concomitantly with Rabisin™ on D21. Group C and D received Recombitek®C6/CV on day 0 and concomitant administration of Recombitek®C6/CV and Rabisin™ on D21. Group E received only Rabisin™ on D21.

Valence Threshold Lepto. sg. Canicola 0.3 logl0 OD50 Lepto. sg. Icterohaem. 0.48 log10 0D50 Lepto. sg. Grippotyphosa 0.43 logl0 ODS0 Lepto. sg. Pomona 1/ 100
Group Day Percentage of respondersn/N 95% CI for percentage Percentage of respondersn/N 95% CI for percentage Percentage of respondersn/N 95% CI for percentage Percentage of respondersn/N 95% CI for percentage
A D35 100% (5/5) [56.6–100.0] 100% (4/4) (51.0–100.0] 100% (5/5) [56.6–100.0] 100% (5/5) [56.6–100.0]
D49 100% (5/5) [56.6–100.0] 100% (5/5) [56.6–100.0] 100% (5/5) [56.6–100.0] 100% (5/5) [56.6–100.0]
D63 100% (5/5) [56.6–100.0] 100% (5/5) [56.6–100.0] 100% (5/5) [56.6–100.0] 100% (5/5) [56.6–100.0]
D84 100% (5/5) [56.6–100.0] 100% (5/5) [56.6–100.0] 100% (5/5) [56.6–100.0] 100% (5/5) [56.6–100.0]
B D35 100% (5/5) [56.6–100.0] 100% (5/5) [56.6–100.0] 100% (5/5) [56.6–100.0] 100% (5/5) [56.6–100.0]
D49 100% (5/5) [56.6–100.0] 100% (5/5) [56.6–100.0] 100% (5/5) [56.6–100.0] 80% (4/5) [37.6,96.4]
D63 100% (5/5) [56.6–100.0] 100% (5/5) [56.6–100.0] 100% (5/5) [56.6–100.0] 80% (4/5) [37.6,96.4]
D84 100% (5/5) [56.6–100.0] 100% (5/5) [56.6–100.0] 100% (5/5) [56.6–100.0] 80% (4/5) [37.6,96.4]
C D35 100% (5/5) [56.6–100.0] 100% (5/5) [56.6–100.0]
D49 100% (5/5) [56.6–100.0] 100% (5/5) [56.6–100.0]
D63 100% (5/5) [56.6–100.0] 100% (5/5) [56.6–100.0]
D84 100% (5/5) [56.6–100.0] 100% (5/5) [56.6–100.0]
D D35 100% (5/5) [56.6–100.0] 100% (5/5) [56.6–100.0]
D49 100% (5/5) [56.6–100.0] 100% (5/5) [56.6–100.0]
D63 100% (5/5) [56.6–100.0] 100% (5/5) [56.6–100.0]
D84 100% (5/5) [56.6–100.0] 100% (5/5) [56.6–100.0]
E D35 0% (0/5) [0.0–43.4] 20% (1/5) [3.6–62.4] 20% (1/5) [3.6–62.4] 0% (0/5) [0.0–43.4]
D49 0% (0/5) [0.0–43.4] 0% (0/5) [0.0–43.4] 0% (0/5) [11.8,76.9] 0% (0/5) [0.0–43.4]
D63 0% (0/5) [0.0–43.4] 0% (0/5) [0.0–43.4] 20% (1/5) [3.6–62.4] 0% (0/5) [0.0–43.4]
D84 0% (0/5) [0.0–43.4] 0% (0/5) [0.0–43.4] 60% (3/5) [23.1–88.2] 0% (0/5) [0.0–43.4]