Table 3.

Results of the statistical non inferiority analysis. The maximum loss of serological efficacy used to demonstrate that the association of the test vaccine is non-inferior to the reference vaccine is set to Δ L = 0.602 on the log₁₀-transformed scale for all valences except Lp, for which Δ L = 2 on the log₂-transformed scale for Lp.

Valence	Test vs. reference	Delta	alpha	Arithm. mean difference (log unit) [1-alpha CI)	Geom. mean ratio[1-alpha CI)	Non-inferiority	p-value
CAV	A vs. B	-0.602	0.05	0.086 [− 0.219, +int)	1.22 [0.60, +int)	Yes	0.0015
	C vs. D	-0.602	0.05	-0.114 [− 0.338, +int)	0.77 [0.46, +int)	Yes	0.0019
CCV	C vs. D	-0.602	0.05	0.080 [− 0.406, +int)	1.20 [0.39, +int)	Yes	0.0155
CDV	A vs. B	-0.602	0.05	-0.132 [− 0.815, +int)	0.74 [0.15, +int)	No	0.1184
	C vs. D	-0.602	0.05	0.512 [− 0.198, +int)	3.25 [0.63, +int)	Yes	0.0097
CPV	A vs. B	-0.602	0.05	0.014 [− 0.329, +int)	1.03 [0.47, +int)	Yes	0.0051
	C vs. D	-0.602	0.05	0.120 [− 0.329, +int)	1.32 [0.47, +int)	Yes	0.0087
CPiV	A vs. B	-0.602	0.05	0.058 [− 0.224, +int)	1.14 [0.60, +int)	Yes	0.0012
	C vs. D	-0.602	0.05	-0.036 [− 0.371, +int)	0.92 [0.43, +int)	Yes	0.0104
Le	A vs. B	-0.602	0.05	0.192 [− 0.059, +int)	1.56 [0.87, +int)	Yes	0.0009
	C vs. D	-0.602	0.05	-0.108 [− 0.238, +int)	O.78 [0.58, +int)	Yes	0.0001
Lg	A vs. B	-0.602	0.05	0.292 [− 0.017, +int)	1.96 [0.96, +int)	Yes	0.0003
Li	A vs. B	-0.602	0.05	0.082 [− 0.312, +int)	1.21 [0.49, +int)	Yes	0.0093
	C vs. D	-0.602	0.05	0.008 [− 0.203, +int)	1.02 [0.63, +int)	Yes	0.0003
Lp	A vs. B	-2	0.05	0.600 [− 0.911, +int)	1.52 [0.53, +int)	Yes	0.0063
Rabies	A vs. E	-0.602	0.05	-0.096 [− 0.476, +int)	0.80 [0.33, +int)	Yes	0.0192
	C vs. E	-0.602	0.05	0.048 [− 0.295, +int)	1.12 [0.51, +int)	Yes	0.0039