. 2022 Apr 2;49(7):5863–5874. doi: 10.1007/s11033-022-07366-5

Table 1.

Impact of DIA on hepatic functions in rats treated with APAP

Parameters	Control	APAP	DIA 25 + APAP	DIA 50 + APAP
ALT (U/L)	25.92 ± 0.55	65.10 ± 1.35^a	38.98 ± 0.80^a,b	30.78 ± 1.06^a,b,c
AST (U/L)	40.25 ± 0.61	85.14 ± 1.22^a	50.64 ± 0.57^a,b	24.67 ± 0.71^a,b,c
TBB (U/L)	17.45 ± 0.59	56.93 ± 0.85^a	30.06 ± 0.34^a,b	24.67 ± 0.71^a,b,c
LDH (U/L)	303.00 ± 1.38	704.00 ± 1.46^a	440.00 ± 2.30^a,b	410.00 ± 1.36^a,b,c

Data are expressed in the form of means ± S.E.M. (n = 6 per group), and one-way ANOVA was utilized for data analysis, followed by Tukey post hoc test. (^a), (^b), (^c): P < 0.05 compared the controls, APAP, DIA 25 + APAP groups respectively

APAP acetaminophen, DIA diacerein, ALT alanine transaminase, AST aspartate transaminase, TBB total bilirubin