Table 2.

Highlighted associations between common variants and opioid response.

Opioids	Outcome	Sex	rsID	Gene	Major	Minor	MAFa	Effect	Direction	P value	Q value	CAVA impact
Codeine/Tramadol	Poor pain control	Male	rs1056837	CYP1B1	G	A	0.433	Synonymous	Risk	7.8 × 10−6	0.0076	Low
			rs1056836	CYP1B1	G	C	0.432	Missense	Risk	8.0 × 10−6	0.0076	Moderate
Hydrocodone/Oxycodone	Poor pain control	All	rs76026520	MACROD2	A	G	0.094	Intronic	Protective	2.1 × 10−5	0.0397	Low
	Adverse events	All	rs35742686	CYP2D6	CT	C	0.019	Nonsense	Protective	7.6 × 10−5	0.1436	High

^aMAF empirical to the current dataset.