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. 2022 Feb 19;41(14):2095–2105. doi: 10.1038/s41388-022-02223-y

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© Crown 2022, corrected publication 2022

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Fig. 6 — a Conditional Tspan6 deletion significantly decreases survival (Kaplan Meier blot) in lung cancer-bearing Tspan6^fl/y Kras^G12D mice as compared to Tspan6^+/y Kras^G12D control littermates. n = 10 per group. *P < 0.05 (Log-rank test). b Representative H&E-stained histological sections of both cohorts 6 weeks after Ad-Cre inhalation. Magnifications ×5. c Representative microCT images to detect lung tumors in Tspan6fl/y Kras^G12D and Tspan6+/y Kras^G12D littermates 8 weeks after Ad-Cre inhalation. d Quantification of hyperplasic regions, adenomas and adenocarcinomas in lungs from Tspan6^fl/y Kras^G12D (n = 5) and control Tspan6^+/y Kras^G12D (n = 5) littermates at the indicated time points following Ad-Cre inhalation. Data are shown as means ± s.e.m. *P < 0.05; **P < 0.01; N.S. = not significant (Student’s t test). e Quantification of % Ki67⁺ cells in hyperplasic regions, adenomas, and adenocarcinomas 4 and 8 weeks post Ad-Cre infection. Data are shown as mean ± s.e.m. *P < 0.05; **P < 0.01; N.S. = not significant (Student’s t test). f p53 ablation in Kras^G12D lung tumors abrogates the survival advantage conferred by Tspan6 expression. Kaplan Meier survival plots are shown for whole-body Tspan6^-/y p53^fl/fl Kras^G12D mice (n = 4) and Tspan6^+/y p53^fl/fl Kras^G12D (n = 6) littermates, and conditional Tspan6^fl/y p53^fl/fl Kras^G12D mice (n = 5) and their respective Tspan6^+/y p53^fl/fl Kras^G12D (n = 8) littermates. A Log-rank test was used for statistical analysis.