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. 2022 Feb 19;41(14):2095–2105. doi: 10.1038/s41388-022-02223-y

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© Crown 2022, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a TSPAN6 expression is significantly reduced in lung cancer (NSCLC) cancers from the GSE10245 cohort with an EMT signature ((NLCLC-EMT) versus an epithelial (NLCLCepith) signature (**p < 0.01)). The TSPAN6 probes used are indicated. b Low TSPAN6 expression levels (Affymetrix probes) predict poor overall survival of lung cancer patients from this cohort. Survival analysis was calculated using a log-rank test. Data presented were obtained using KM plotter. P values (log-rank test) and total numbers of patients with either low (black) or high (red) TSPAN6 expression are indicated. c TSPAN6 expression is significantly reduced in pancreatic adenocarcinoma (PDA) cancers with an EMT signature (PDA-exoc and PDA-QM) relative to those with an epithelial signature (PDA-epith) in the GSE17891 and GSE11838 cohorts. d Low TSPAN6 expression is correlated with poor survival in pancreatic ductal carcinoma patients from these cohorts (data presented as in b). Green bar-TSPAN6 low expression identifies PDA patients with advanced disease and early relapse with lethal outcome (18–24 months). NSCLCepith Non-Small Cell Lung Cancer epithelial subclass, NSCLCmes Non-Small Cell Lung Cancer mesenchymal subclass [36]; PDAepith Pancreatic Ductual Adenocarcinoma epithelial subclass, PDAexocrine Pancreatic Ductual Adenocarcinoma exocrine subclass, PDA-QM Pancreatic Ductual Adenocarcinoma quasi-mesenchymal subclass [37].