Fig. 1.

Fibrin hydrogels in regenerative medicine. a Fibrin hydrogels provide a transient matrix for tissue engineered grafts that mimics the provisional matrix of physiological tissue regeneration, conducive to progenitor proliferation and differentiation, as well as to rapid invasion by host-derived blood vessels. b Several protein engineering approaches have been developed to decorate fibrin hydrogels with recombinant morphogens and growth factors. These approaches enable the use of fibrin hydrogels as tunable platforms for controlled release of factors in vivo to guide endogenous tissue repair, as well as to provide specific morphogenic microenvironments to seeded progenitors in tissue-engineered grafts