TABLE 1.

Patient demographics and indinavir PK parameters

Patient	Dose/BSA (mg q8h/m2)	Age (yr)	Sexa	Wt (kg)	Ht (cm)	BSA (m2)	BMI	CDCb classification	Baseline			Indinavir PK parameters
									No. of CD4+ cells/μl	%CD4	Viral load (log no. of copies/ml)	Cmax (mg/liter)	Tmaxc (h)	Cmin (mg/liter)	AUC (mg × h/liter)	CL/Fd (liters/h)	t1/2e (h)
1	556	9.6	M	31.0	137	1.08	17	C2	602	21.5	4.18	8.3	1.5	0.051	25.2	23.8	0.84
2	441	10.0	M	47.5	145	1.36	23	B2	669	27.0	3.08	14.1	1.5	0.050	30.7	19.6	0.87
3	550	11.6	M	30.0	142	1.09	15	C3	60	2.8	3.87	11.5	1.0	0.046	45.3	13.3	0.56
4	455	10.0	M	46.2	144	1.32	22	C2	547	21.3	3.96	12.7	1.0	0.056	26.0	23.1	0.87
5	455	10.2	F	22.1	128	0.88	14	C3	10	0.9	3.97	16.6	2.0	0.095	55.1	7.3	0.66
6	522	11.6	M	33.9	141	1.15	17	C2	470	26.9	2.46	7.1	2.0	0.073	25.0	24.1	0.65
7	465	9.0	F	21.7	123	0.86	14	B2	472	29.0	4.92	28.8	2.0	0.800	117.0	3.4	0.90
8	522	11.0	F	33.0	145	1.15	16	C2	300	15.0	3.88	14.8	2.0	0.130	49.0	12.3	0.68
9	488	13.6	M	56.0	171	1.64	19	B3	25	1.4	4.23	7.3	2.0	0.071	19.1	42.0	0.89
10	496	12.1	M	36.4	145	1.21	17	A2	365	18.0	3.74	11.0	2.0	0.095	41.6	14.4	0.71
11	533	12.1	F	47.2	167	1.50	17	A2	336	28.0	4.43	3.2	4.0	0.113	15.9	50.3	0.83
Mean	498	11.0		36.8	144	1.20	17		351	17.4	3.88	12.3	1.9	0.144	40.9	21.2	0.77
SD	41	1.4		11.1	14	0.24	3		233	11.0	0.66	6.7	0.8	0.219	28.3	14.1	0.12
%CVf	8	12		30	10	20	17		66	63	17	55	42	153	69	67	15

^aM, male; F, female. 

^bCDC, Centers for Disease Control and Prevention. 

^cT_max, time to C_max. 

^dCL/F, clearance/bioavailability. 

^et_1/2, elimination rate constant. 

^f%CV, Percent coefficient of variation.