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. 2022 Apr 1;13:1744. doi: 10.1038/s41467-022-29394-2

Fig. 7. Structural models of the CcmEFH complex from E. coli.

Fig. 7

a CcmE is believed to deliver heme to CcmF. Two views of a top model generated by AF2Complex are shown in the cartoon representation. The inset shows the key heme handling residues, His130 and Tyr134 of CcmE and the two histidines of CcmF. b Two heme molecules computationally placed in the expected heme-binding sites of CcmF using the model shown in (a). The critical heme Fe-coordinating residues, His173 (P-His1) and His303 (P-His2) for the P-heme delivered by CcmE and eventually attached to an apo-cytochrome c protein and His261 (TM-His1) and His461 (TM-His2) for the cofactor TM-heme are also shown.