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. 2022 Apr 1;12:5511. doi: 10.1038/s41598-022-09529-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation between glutamine uptake in magnetic resonance imaging (MRI) and the expression of ASCT2 and CSC markers. (a) The xenograft HT29 tumor, which showed both strong glutamine uptake (marked in red) and weak glutamine uptake (marked in blue) in the MRI image was sectioned to verify the MRI results. The image of the tumor below was obtained after IHC staining for ASCT2 expression. Scale bar = 2 mm. (b) IHC staining for ASCT2, GLS, SNAT2, CD44, and CD166 expression in tumor regions that show strong (top row, outlined in red) and weak (bottom row, outlined in blue) glutamine uptake. Scale bar = 50 μm (c) The t-test results of IHC scores (ASCT2, CD44, and CD166). (n = 5 biologically independent samples per group).