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. 2022 Apr 1;12:5511. doi: 10.1038/s41598-022-09529-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Decreased glutamine uptake in MRI due to the pharmacological inhibition of ASCT2 expression. (a) Comparison of representative glutamine MRI images (vehicle vs V-9302 treated) from a single mouse at a similar location. (b) The sum of the intensity of pixels that show a change higher than 4% (s_int) is plotted as a function of post-injection time for all six mice. (c) Data in (b) were divided by the tumor size (a_tumor) to account for the tumor growth during the 3 days between MRI scans. (d) p values (p1 from the t-test of s_int (b)) and p2 from the t-test of s_int/a_tumor (c) are presented for the post-injection time. (e) The tumor area as a number of pixels that show a change higher than 4% (a_int). It shows reduced glutamine uptake in V-9302-injected mice. (f) The relative area of a_int in the whole tumor, calculated using the formula (a_int/a_tumor) × 100.