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. 2021 Jul 27;43(4):876–888. doi: 10.1038/s41401-021-00712-6

Fig. 3. Effects of cocaine self-administration on CB1 and CB2 mRNA expression (by qRT-PCR).

Fig. 3

a Mean numbers of cocaine self-administration (infusions) or oral sucrose deliveries during the 4 weeks of self-administration training; cocaine, but not sucrose, self-administration significantly upregulated CB2 mRNA expression in both the PFC and striatum in WT mice measured with the mCB2A (b) and mCB2-KO (c) probes, respectively.  *P < 0.05, **P < 0.01, ***P < 0.001, compared to drug naïve mice or sucrose self-administration mice.