Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 1;13:1751. doi: 10.1038/s41467-022-29409-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — a Colony-forming assay to examine proliferative potential of hematopoietic progenitors from fetal liver isolated from 16.5dpc embryos of different genotypes. LP/LP and LP/KO showed reduced number of compact colonies. Inset shows morphology of scattered colonies. b Quantification of colony numbers for indicated genotype shows reduced number of compact LP/LP and LP/KO colonies and higher number of scattered LP/LP and LP/KO colonies (n = 3 biological replicate, two-tailed Students t-Test, error bar- SD of mean). c Kaplan–Meier survival curve of lethally radiated recipient mice after bone marrow reconstitution by fetal liver cells of indicated genotypes. LP/KO fetal liver cells show reduced bone marrow reconstitution leading to shorter median survival of the recipients (n = 10, p = 0.0003, Log-rank Mantel–Cox test). All other genotypes showed no significant difference in survival. d Kaplan–Meier survival curve of lethally radiated recipient mice after secondary transplantation using bone marrow from primary transplantation recipients. LP/LP bone marrow reconstitution shows significantly reduced median survival as compared to WT (n = 10, p = 0.041, Log-rank Mantel-Cox test).