Table 1.
Demographic and Baseline Clinical Characteristics
| Group |
|||
|---|---|---|---|
| Characteristic | Control (n=24) | FD (n=40) | P Value |
| Age, y | 40 (13) | 42 (13) | .7 |
| Body mass index, kg/m2 | 26.1 (4.7) | 26.7 (6.6) | .9 |
| Women | 14 (58) | 31 (78) | .2 |
| Mean (SD) NDI dyspepsia symptom severity score a | 12.95 (12.5-13.0) | 10.8 (10.03-11.41) | <.001 |
| Mean (SD) NDI QOL score b | 100 (100-100) | 41.3 (18.6-62.1) | <.001 |
| PAGI-SYM subscores, Median (IQR) c | |||
| Heartburn | 0 (0-0.14) | 1.86 (1.14-2.55) | <.001 |
| Nausea, vomiting, and regurgitation | 0 (0-0) | 1 (0.33-2.33) | <.001 |
| Early satiety | 0 (0-0.25) | 3.1 (2.5-4.0) | <.001 |
| Bloating | 0 (0-0.13) | 3.5 (2.5-4.63) | <.001 |
| Upper abdominal pain | 0 (0-0) | 3.5 (2.38-4.0) | <.001 |
| Anxiety, n d | |||
| Borderline | 0 | 7 | .04 |
| Definite | 0 | 11 | .005 |
| Depression, n | |||
| Borderline | 0 | 8 | .02 |
| Definite | 0 | 3 | .3 |
| Mean (SD) GE thalf for solids, min | 103.8 (32.5) | 122.6 (35.0) | .02 |
| Mean (SD) GE thalf for liquids, min | 16 (5) | 22 (10) | .004 |
| Colonic filling at 6 hours, % | 56 (21) | 40(18) | .004 |
GE, gastric emptying; NDI, Nepean Dyspepsia Index; FD, nonulcer dyspepsia; PAGI-SYM, Patient Assessment of Upper Gastrointestinal Disorders-Symptom Severity; QOL, quality of life.
a
Least and most severe symptoms are 13 and 0
b
Best and worst QOL are 100 and 0
c
Least and most severe symptoms are respectively 0 and 5
d
Borderline and definite anxiety (or depression) are 8-10 and 11-21